Paradoxes of Immunity and Immunosuppression in Salmonella Infection

  • Toby K. Eisenstein
  • Niloofer Dalal
  • Loran Killar
  • Joo-Chiang Lee
  • Rosana Schafer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 239)

Abstract

There is continuing interest in mechanisms of immunity to systemic Salmonella infection, as concepts regarding the relative contributions of humoral and cellular immunity to host defense against these organisms form the theoretical basis for development of improved vaccines against typhoid fever (1,2). (Experimentally, investigations are carried out using a mouse model of systemic infection with Salmonella typhimurium as S. typhi is not virulent for mice.) Although the current typhoid vaccine, consisting of acetone-killed cells, has been shown to be protective in humans (3), it has an undesirable level of toxicity (1). Recent efforts have focused on live, attenuated strains of S. typhi which can be given orally, as an alternative vaccine strategy. A galE mutant, Ty21a, has been shown to have efficacy in a field trial in Egypt (4) although results have been less promising in field trials in Chile (5). One drawback of the Ty2la strain is that the exact nature of the genetic lesions which confer loss of virulence are not known (6). Stocker and colleagues have developed a series of mutants in various species of Salmonella which are blocked in aromatic synthesis due to transposon-mediated gene deletions or inversions (7,8). Based on high levels of protection induced in mouse models of typhoid fever using these aroAstrains of S. typhimurium Stocker has developed attenuated S. typhi with similar types of lesions for potential use in humans against typhoid fever (9). In addition, there is also considerable interest in using these aro-strains as vectors for cloned genes of other organisms such as E. coli enterotoxins (10,11).

Keywords

Spleen Cell Typhoid Fever Peritoneal Cell SL3235 Cell Tumor Cytotoxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Toby K. Eisenstein
    • 1
  • Niloofer Dalal
    • 1
  • Loran Killar
    • 1
  • Joo-Chiang Lee
    • 1
  • Rosana Schafer
    • 1
  1. 1.Department of Microbiology and ImmunologyTemple University School of MedicinePhiladelphiaUSA

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