Neuritic Responses to GM1 Ganglioside in Several in Vitro Systems

  • Silvio Varon
  • Stephen D. Skaper
  • Ritsuko Katoh-Semba
Part of the FIDIA Research Series book series (FIDIA, volume 6)

Abstract

In explant or monolayer neural cultures, a neuron is subject to various influences from the medium, the substratum, and the other cells present. Medium components also alter the substratum properties, and cultured cells modify both medium and substratum besides themselves via direct contacts. This multiplicity of influence sources applies in vivo, and in pathological as well as normal circumstances. If the balance of such extrinsic influences is already optimal for the neural performance to be investigated, then experimental interventions cannot reveal agents with a promoting effect but only agents with an inhibiting influence. To seek and investigate a beneficial (promoting) agent one must rely on restrictive circumstances, either imposed experimentally or occuring naturally as may be the case in developmental or pathological situations.

Keywords

PC12 Cell Neuritic Outgrowth Lipid Synthesis PCI2 Cell FIDIA Research 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CNS

central nervous system

PNS

Peripheral nervous system

NGF

nerve growth factor

CNTF

ciliary neuronotrophic factor

DRG

dorsal root ganglion.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Silvio Varon
    • 1
  • Stephen D. Skaper
    • 1
  • Ritsuko Katoh-Semba
    • 2
  1. 1.Department of Biology, School of MedicineUniversity of California, San DiegoLa JollaUSA
  2. 2.Department of Perinatology Institute for Developmental ResearchAichi Prefectural Colony, Kasugi, AichiJapan

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