Concepts of Ganglioside Metabolism
Gangliosides (Fig. 1),although characteristic components of all mammalian plasma membranes, are highly abundant in nervous tissues only. They are arranged asymmetrically in the outer leaflet of cellular membranes, their carbohydrate chains facing the extracellular space. Little is known about their function and about the regulation of their metabolism, the elucidation of which might be helpful in understanding the pathogenetic mechanisms underlying the clinical symptoms of ganglioside storage diseases.
KeywordsSkin Fibroblast Total Lipid Extract Cerebellar Cell Lysosomal Fraction Mammalian Plasma Membrane
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- Schwarzmann G and Sandhoff K (1983) in: Chester MA, Heinegârd D, Lundbland A, Svensson S (eds): Proceedings of the 7th International Symposium on Glycoconjugates. University of Lund, Sweden, pp. 238–239.Google Scholar