Human 17β-Hydroxysteroid Dehydrogenase Type 5 is Inhibited by Dietary Flavonoids

  • A. Krazeisen
  • R. Breitling
  • G. Möller
  • J. Adamski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 505)

Abstract

Phytoestrogens contained in a vegetarian diet are supposed to have beneficial effects on the development and progression of a variety of endocrine-related cancers. We have tested the effect of a variety of dietary phytoestrogens, especially flavonoids, on the activity of human 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD 5), a key enzyme in the metabolism of estrogens and androgens. Our studies show that reductive and oxidative activity of the enzyme are inhibited by many compounds, especially zearalenone, coumestrol, quercetin and biochanin A. Among flavones, inhibitor potency is enhanced with increased degree of hydroxylation. The most effective inhibitors seem to bind to the hydrophilic cofactor binding pocket of the enzyme.

Keywords

Glycyrrhetinic Acid Abietic Acid Dehydrogenase Type Hydroxysteroid Dehydrogenase Dietary Phytoestrogens 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • A. Krazeisen
  • R. Breitling
  • G. Möller
  • J. Adamski
    • 1
  1. 1.GSF-National Research Center for Environment and Health, Institute for Experimental GeneticsGenome Analysis CenterNeuherbergGermany

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