Industrial Production of L-Malic Acid by Immobilized Microbial Cells

  • I. Chibata
  • T. Tosa
  • K. Yamamoto

Abstract

Recently, industrial applications of immobilized microbial cells as well as immobilized enzymes have been undergoing development. In 1969, we succeeded in industrializing a process for continuous optical resolution of DL-amino acid using immobilized aminoacylase, which was prepared by ionic binding of mold aminoacylase to DEAE-Sephadex (1). By using this immobilized enzyme system the costs for producing optically active amino acids such as L-methionine, L-phenylalanine, L-tryptophan and L-valine were significantly reduced. This is reputed to be the first industrial application of immobilized enzymes in the world.

Keywords

Succinic Acid Immobilize Enzyme Immobilize Cell Fumaric Acid Bile Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    CHIBATA, I., TOSA, T., SATO, T., MORI, T. & MATUO, Y. In “Proc. IVth Internat. Fermentation Symposium: Fermentation Technology Today” (Ed. G. Terui) Soc. Fermentation Technology, Japan 1972, p. 383.Google Scholar
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • I. Chibata
    • 1
  • T. Tosa
    • 1
  • K. Yamamoto
    • 1
  1. 1.Research Laboratory of Applied BiochemistryTanabe Seiyaku Co. Ltd.OsakaJapan

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