Endotoxin pp 549-556 | Cite as

The Mediation of Endotoxin-Induced Beneficial Effects by Cytokines

  • R. Urbaschek
  • B. Urbaschek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 256)

Abstract

Endotoxins, when entering the circulation in sufficient amounts, elicit multiple effects that can lead to shock and death. Besides these detrimental effects, endotoxins in minute concentrations may nonspecifically contribute to regulate the steady state of host defense. Moreover, various experimental approaches have shown, already in the early years of endotoxin research, that injection of small amounts of extracted endotoxins can induce beneficial effects, such as tolerance to the pyrogenic and lethal effects of endotoxin, nonspecific resistance to microbial infections and irradiation disease, stimulation of hematopoiesis, as well as tumor regression. These beneficial effects of endotoxins have been reviewed recently (13).

Keywords

Tumor Necrosis Factor Kupffer Cell Lethal Effect Cecal Ligation NMRI Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • R. Urbaschek
    • 1
  • B. Urbaschek
    • 1
  1. 1.Department of Immunology and Serology, Institute of Medical Microbiology and Hygiene, Klinikum MannheimUniversity of HeidelbergMannheimGermany

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