Comparative Study of Lipopolysaccharide-, Lipid IVa-, and Lipid X-Induced Tumor Necrosis Factor Production in Murine Macrophage-Like Cell Lines
Tumor necrosis factor (TNF) was initially described in the sera of Mycobacterium bovis strain BCG infected mice treated with endotoxin (2) and defined by its ability to cause necrosis of tumors in mice. In addition to this potentially beneficial effect, TNF has been shown to be intimately involved in the pathophysiology of bacterial lipopolysaccharide (LPS)-induced shock and lethality in mice (1). In both instances, the primary sources of TNF are macrophages (5).
KeywordsMYcobacterium Bovis Tumor Necrosis Factor Production Tumor Necrosis Factor Activity Induce Tumor Necrosis Factor Production Tumor Necrosis Factor Content
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