Biochemical mechanisms of resistance to antimicrobial drugs
conversion of the active drug to an inactive derivative by enzyme(s) synthesized by the resistant cells;
- 2.loss of sensitivity of the drug target site as a result of:
covalent modification by enzyme activity in the resistant cells
mutation(s) affecting the target, or
acquisition of genetic information encoding either a drug-resistant form of the target enzyme or overproduction of the drug-sensitive enzyme.
Removal of the drug from the cellular interior by drug efflux systems located in the cell envelope.
KeywordsClavulanic Acid Drug Efflux Chloramphenicol Acetyl 1411 Transferase Drug Efflux Pump Acetyl Coenzyme
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