Immobilization Osteoporosis

  • B. Jenny Kiratli

Abstract

Bone loss occurs with inactivity and immobilization. Just as bone mass increases during growth and development and with exercise attributable to increases in mechanical loading, bone mass decreases with reduced mechanical use. This response has been recognized for more than 50 years and has been evaluated in many clinical conditions. However, much remains unknown about underlying mechanisms, and there have been few successful demonstrations of countermeasures for prevention or treatment. Clinical immobilization includes a variety of situations, ranging from temporary recumbency during recovery from surgery, to permanent paralysis resulting from a traumatic spinal cord injury, and site-specific bone loss occurs relative to the magnitude of immobilization. Although osteopenia has been reported in diseases and conditions that cause temporary or partial immobilization, few detailed studies have been conducted and available information is fairly general. A larger body of literature concerns bone loss with complete paralysis due to spinal cord injury [1]. The concepts discussed here related to bone response to paralysis are expected to apply to other, less extensive immobilizing conditions, but with reduced magnitude.

Keywords

Bone Mineral Density Bone Loss Spinal Cord Injury Bone Mass Fracture Risk 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2003

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  • B. Jenny Kiratli

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