Preservation of Oxidative Phosphorylation by Lidocaine in Ischemic and Reperfused Myocardium

  • D. W. Baron
  • M. Sunamori
  • C. E. Harrison

Abstract

The effect of lidocaine (2 mg/kg bolus, 0.04 mg/kg per min infusion) on ischemic and reperfused myocardial respiration was assessed in 32 dogs, using indices of mitochondrial respiration (ADP:O ratio, state 3 and state 4 respiration, and respiratory control index). Heart rate, left ventricular (LV) pressure, LV dp/dt, cardiac index, epicardial ST segment, and regional myocardial blood flow, using 9 ± 1 μm radiospheres, were measured after 40 min of constriction of the anterior descending coronary artery (N = 16) and after 20 min of reperfusion (N = 16). Results showed that lidocaine increased state 3 respiration and respiratory control in reperfused myocardium (P < 0.05) with both glutamate and succinate-rotenone as substrate. It is concluded that lidocaine improves postischemic mitochondrial oxidative phosphorylation independent of altered hemodynamics or change in myocardial blood flow.

Keywords

Cardiac Index Myocardial Blood Flow Respiratory Control Reperfused Myocardium Cell Volume Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • D. W. Baron
    • 1
  • M. Sunamori
    • 1
  • C. E. Harrison
    • 1
  1. 1.Cardiac Muscle Research LaboratoryMayo Clinic and Mayo FoundationRochesterUSA

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