Pathogenesis and Prophylaxis of Cardiac Lesions in Stress

  • F. Z. Meerson

Abstract

Emotional or painful stress excites the brain centers which trigger stress reactions, this excitement being followed by an increase in catecholamine concentration. The following chain of events is thought to occur under the influence of the catecholamine excess: activation of lipid peroxidation in the membranes; labilization of lysosomes; damage to sarcolemmal membranes which are responsible for calcium transport; increased calcium concentration in the heart sarcoplasm. The contraction of myofibrils, the decrease in efficiency of ATP resyn-thesis in the mitochondria, and the activation of Phosphorylase and proteases all arise from the calcium excess. This results in necrotic foci and alterations of heart function. The damages can be effectively prevented by suppression of stress-responding centers with 7-aminobutyric acid, blockade of β receptors with propranolol, inhibition of lipid peroxidation by antioxidants, inhibition of proteolytic lysosomal enzymes with trasilol, or blocking of calcium entry into the myocytes with verapamil. The possible application to clinical practice of chemical prophylaxis of stress damage in the heart is discussed.

Keywords

Schiff Base Contractile Function Stress Damage Orotic Acid Painful Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bergmeyer, H. U. 1970. Methode der Enzymatische Analyse. Verlag Chemie, Weinheim.Google Scholar
  2. 2.
    Desiderato, O., MacKinnon, J. R., and Nisson, H. 1974. Development of gastric ulcers in rats following stress termination. J. Comp. Physiol. Psychol. 87:208–214.PubMedCrossRefGoogle Scholar
  3. 3.
    Fallen, E. J., Elliot, W., and Gorlin, R. 1967. Apparatus for study of ventricular function and metabolism in the isolated perfused rat heart. J. Appl. Physiol, 22:836.PubMedGoogle Scholar
  4. 4.
    Folch, J., Lee, M., and Stanley, G. H. S. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497–509.PubMedGoogle Scholar
  5. 5.
    Kagan, V. J., Churakova, T. D., Karagodin, V. P., Arkhipenko, Y. V., Bilenko, M. V., and Kozlov, Y. P. 1979. [Disturbances of the fermentative systems of calcium transport in the membranes of sarcoplasmic reticulum under the action of the hydroperoxides, phospholipid, and the hydroperoxides of the fatty acids.] Biull. Eksp. Biol. Med. 2:145–149.Google Scholar
  6. 6.
    Kogan, A. K., Kudrin, A. N., and Nikolaev, S. M. 1976. [On the role of free radical lipid peroxidation in the mechanism of myocardium lesion by adrenaline.] In: Svobodnoradikalnoe Okislenie Lipidov v Norme i Patologii (Yu. M. Petrusevitch, ed.), Nauka, Moscow.Google Scholar
  7. 7.
    Kudrin, A. N., Kogan, A. K., Strukov, A. I., Nikolaev, S. M., and Kaktursky, L. B. 1975. [Antioxidants and the infarct of the myocardium.] In: Abstracts, Second International Congress on Pathological Physiology, Prague, July 8–11, p. 216.Google Scholar
  8. 8.
    Meerson, F. Z. 1980. Disturbances of metabolism and cardiac function under the action of emotional painful stress and their prophylaxis. Basic Res. Cardiol. 75(4):479–500.PubMedCrossRefGoogle Scholar
  9. 9.
    Meerson, F. Z. 1980. Prevention by antioxidants of cardiac lesions caused by stress, hypoxia and ischemia. In: Abstracts, VIII European Congress of Cardiology. Paris, June 22–26, p. 18.Google Scholar
  10. 9a.
    Meerson, F. Z., Arkhipenko, Yu. V., Kozhitskaya, I.I., and Kagan, V. E. 1981. [Damage of the sarcoplasmic Ca2-transporting system of the heart under emotional-pain stress.] Bull. Eksp. Biol. Med. 4:406–406.Google Scholar
  11. 10.
    Meerson, F. Z., Belkina, L. M., Igolev, A. A., Golubeva, L. U., and Abdikaliev, N. A. 1980. [Application of antioxidants for the prevention of the experimental infarct of myocardium and reoxigenisational disturbances of the cardiac functions.] Kardiologiia 10:81–86.Google Scholar
  12. 11.
    Meerson, F. Z., Giber, L. M., Markovskaja, G. I. and Radzievskiy, S. A., Rozitskaja, I. I., Kogan, A. K., 1977. [Prophylaxis of the disturbance of the contractile function of heart and ulcerous damages of stomach in emotional stress with sodium oxibutirate and vitamin E.] Dokl. Akad. Nauk SSSR 237:1230–1233.PubMedGoogle Scholar
  13. 12.
    Meerson, F. Z., Gorina, M. S., Zeland, A. M., and Giber, L. M. 1979. [Effect of emotional painful stress on the contractile function and the adrenoeactivity of myocardium.] Biull. Eksp. Biol. Med. 11:528–530.Google Scholar
  14. 13.
    Meerson, F. Z., Kagan, V. E., Golubeva, L. U., Ugolev, A. A., Snimkovich, M. V., Giber, L. M., and Rozitskaja, J. J. 1979. [Prevention of stress and hypoxic affections of the heart with antioxidant ionol.] Kardiologiia 8:108–111.Google Scholar
  15. 14.
    Meerson, F. Z., Kagan, V. E., Prilipko, L. L., and Rozitskaja, J. J. 1981. [Inhibition of the activation of the peroxide oxidation of lipids in emotional painful stress by ionol and gamoxibutirate.] Biull. Eksp. Biol. Med. 12:661–663.Google Scholar
  16. 15.
    Meerson, F. Z., Kagan, V. E., Prilipko, L. L., Rozitskaja, I.I., Giber, L. M., and Kozlov, Tu. P. 1979. [Activation of the peroxide oxidation of lipids in emotional painful stress.] Biull. Eksp. Biol. Med. 10:404–406.Google Scholar
  17. 16.
    Meerson, F. Z., Malyshev, V. V., Kagan, V. E., Treshuk, L. I., and Rozitskaja, I.I. 1980. [Activation of the peroxide oxidation of lipids and focal contractural lesions in myocardium in emotional painful stress.] Arch. Pathol. 42(2):9–12.Google Scholar
  18. 17.
    Meerson, F. Z., Malyshev, V. V., Popova, N. S., and Markovskaja, G. I. 1979. [Decrease in stress reaction and ulcerous damages of stomach under the action of GABA.] Biull. Eksp. Biol. Med. 12:659–661.Google Scholar
  19. 18.
    Meerson, F. Z., Pavlova, V. I., Kamilov, F. K., and Yakushev, V. S. 1979. [Application of sodium gamoxybutyrate for the prophylaxis of lesions caused by emotional painful stress.] Patol. Fiziol. Eksp. Ter. 3:26–31.PubMedGoogle Scholar
  20. 19.
    Meerson, F. Z., Shimkovich, M. V., and Horunzji, V. A. 1980. [Effect of emotional painful stress on the reactivity of myocardium to the changes in calcium concentration.] Biull. Eksp. Biol. Med. 3:272–274.Google Scholar
  21. 20.
    Meerson, F. Z., and Trihpoeva, A. M. 1981. [Prevention of disturbances of the contractile function of myocardium appearing after emotional painful stress by gamoxybutyrate and antioxidant ionol.] Biull. Eksp. Biol. Med. 11:531–533.Google Scholar
  22. 21.
    Meerson, F. Z., and Ugolev, A. A. 1980. [Disturbance of the membrane transport of calcium as a common link in the pathogenesis of the different forms of cardiac insufficiency.] Kardiologiia 1:68–75.Google Scholar
  23. 22.
    Neely, J. R., Libermeister, H., Battersby, E. J., and Morgan, H. E. 1967. Effect of pressure development on oxygen consumption by isolated rat heart. Am. J. Physiol. 212:804–814.PubMedGoogle Scholar
  24. 23.
    Semenova, L. A., and Tsellarius, U. G. 1978. [Ultrastructure of Heart Muscle Cells in Focal Metabolitic Lesions.] Nauka, Novosibirsk.Google Scholar
  25. 24.
    Sonnenblick, E. H. 1962. Force-velocity relation in mammalian heart muscle. Am. J. Physiol. 202:931–939.PubMedGoogle Scholar
  26. 25.
    Spikerman, P. G., Gobhard, M. M., and Nordbac, H. 1975. Myocardial high energy phosphates and enzyme release during anaerobiosis in the isolated perfused dog heart. In: Abstract. International Study Group for Research in Cardiac Metabolism, Brussels. p. 41.Google Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • F. Z. Meerson
    • 1
  1. 1.Institute of General Pathology and Pathologic PhysiologyUSSR Academy of Medical SciencesMoscowUSSR

Personalised recommendations