Pseudoephedrine Effects on Milk Production in Women and Estimation of Infant Exposure via Human Milk

  • T. Hale
  • K. Ilett
  • P. Hartmann
  • K. Aljazaf
  • L. Mitoulas
  • J. Kristensen
  • L. Hackett
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 554)

Abstract

There have been numerous anecdotal reports that pseudoephedrine use results in decreased milk production (Anderson 2000). This study was carried out to determine milk production, plasma prolactin levels, blood flow to the breast, and milk levels of pseudoephedrine following a maternal dose of 60 mg. Pseudoephedrine is a sympathomimetic amine (alpha-adrenoceptor agonist) that enjoys wide use as a nasal mucous membrane and sinus decongestant. The drug has been detected in the milk of three nursing mothers (at 3, 3, and 18 months of lactation) after ingestion of a single dose of a combined pseudoephedrine HC1 60 mg /triprolidine HC1 2.5 mg tablet (Findlay et al. 1984). The average concentration in milk over 24 hours was 264 µg/L. Although milk production was not measured, it was calculated that this would correspond to a relative infant dose of around 5% of the weight-adjusted maternal dose.

Keywords

Milk Production Nasal Mucous Membrane Nursing Mother Plasma Prolactin Level Princess Margaret Hospital 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Anderson PO. Decongestants and milk production. J Hum Lact 2000; 16:294.PubMedGoogle Scholar
  2. Findlay JW, Butz RF, Sailstad JM, Warren JT, Welch RM. Pseudoephedrine and triprolidine in plasma and breast milk of nursing mothers. Br J Clin Pharmacol 1984;18:901–906.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • T. Hale
    • 1
  • K. Ilett
    • 1
  • P. Hartmann
    • 1
  • K. Aljazaf
    • 1
  • L. Mitoulas
    • 1
  • J. Kristensen
    • 1
  • L. Hackett
    • 1
  1. 1.King Edward Memorial & Princess Margaret Hospital, The Western Australian Centre for Pathology and Medical ResearchTexas Tech University Health Sciences Center, University of Western Australia, Curtin University of TechnologyAustralia

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