The body’s ability to maintain core temperature within a very precisely defined range is truly remarkable. Intricate physiologic mechanisms are constantly at work to prevent wide swings in body temperature despite the effects of changing environmental conditions. These mechanisms take place subconsciously and are vital to the preservation of normal subcellular, cellular, organ, and total body function. Significant alterations in these mechanisms, resulting in profound elevation or depression of core temperature, may be life threatening. Heatstroke and profound hypothermia are the two major medical emergencies of disordered thermoregulation encountered in clinical practice, with malignant hyperthermia representing a special case of elevated core temperature.
KeywordsCore Temperature Core Body Temperature Malignant Hyperthermia Heat Illness Dantrolene Sodium
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