Regulation of Food Intake and Body Weight

  • Michael W. Schwartz
  • Denis G. Baskin
  • Karl J. Kaiyala
  • Steven C. Woods
  • Daniel PorteJr.
Chapter
Part of the Contemporary Biomedicine book series (CB, volume 15)

Abstract

The concept that body adiposity is homeostatically regulated is rooted in the observation that most mammals maintain a stable level of adiposity over long time periods. Since the amount of the body’s energy that is stored as adipose tissue is determined by the net difference between caloric intake and expenditure, this observation suggested to early investigators that energy intake and expenditure must be balanced with some precision (1,2). Rejecting the notion that maintenance of energy balance could be achieved by random processes, investigators proposed many decades ago that food intake and adipose mass are coupled elements of a homeostatic regulatory loop. This view was supported by the discovery that changes in energy expenditure and adiposity elicit compensatory changes in caloric intake. In 1953, these observations led Kennedy (3) to propose that changes in body adiposity are signaled to the brain, thereby modifying the drive to eat. Subsequently, other investigators postulated that a change in adiposity also elicits adaptive changes in energy expenditure, a view now supported by a large body of literature (1,4) that includes studies in humans (5). Through these mechanisms, adiposity-proportional afferent signals were proposed to enable the brain to restore adipose mass to its regulated level. Obesity was viewed, therefore, as a disorder arising from impaired body weight regulation, rather than a lack of dietary restraint.

Keywords

Food Intake Brown Adipose Tissue Arcuate Nucleus Body Adiposity Circulate Insulin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Michael W. Schwartz
  • Denis G. Baskin
  • Karl J. Kaiyala
  • Steven C. Woods
  • Daniel PorteJr.

There are no affiliations available

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