Sepsis pp 1-14 | Cite as

Physiopathology of Sepsis

  • Marco A. Perafán


Infection occurs in 15% to 40% of admissions to the intensive care unit (ICU); mortality ranges from 10% to 80%. The EPIC (European prevalence of infection in intensive care) European study, with 10,038 patients, found that 21% of patients enter intensive care: 65% with pneumonia, 17% with urinary infection, and 12% with bacteremia. The most frequently found germs were the following: enterobacteria (34%), Staphylococcus aureus (30%), and Pseudomonas aeruginosa (30%). The risk factors observed in the study were the following: prolonged stay, mechanical ventilation, trauma, central venous catheter, and urinary catheter. Only 50% of blood growths were positive in sepsis patients.1


Tumor Necrosis Factor Nitric Oxide Septic Shock Severe Sepsis Right Ventricle 
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© Springer Science+Business Media New York 2004

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  • Marco A. Perafán

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