cAMP Signal Transduction Abnormalities in the Pathophysiology of Mood Disorders: Contributions from Postmortem Brain Studies

  • Annisa Chang
  • Peter P. Li
  • Jerry J. Warsh
Part of the Neurobiological Foundation of Aberrant Behaviors book series (NFAB, volume 4)

Abstract

During the past decade, considerable advances have been made in second messenger and signal transduction research in mood disorders. In this chapter, evidence derived from human postmortem brain studies is reviewed which supports the emerging view that postreceptor disturbances in G protein-linked cAMP signaling pathways play a major role in the pathophysiology of bipolar (BD) and major depressive disorders (MDD). In addition, the pathophysiological implications of the available evidence are also discussed, within the context of findings from recent neuroimaging and neuropathological studies.

Keywords

Mood Disorder Postmortem Brain cAMP Response Element Binding cAMP Signaling Bipolar Affective Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Annisa Chang
  • Peter P. Li
  • Jerry J. Warsh

There are no affiliations available

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