Ovarian Cancer pp 161-183 | Cite as

Normal Ovarian Surface Epithelium

  • Alice S. T. Wong
  • Nelly Auersperg
Part of the Cancer Treatment and Research book series (CTAR, volume 107)

Abstract

The ovarian surface epithelium (OSE) is the part of the pelvic mesothelium that covers the ovary. It is also referred to in the literature as ovarian mesothelium (OM) (1, 2) or normal ovarian epithelium (NOE) (3), and it used to be called ‘germinal epithelium’ because it was mistakenly believed to give rise to germ cells. Because of its inconspicuous appearance and apparent lack of significant functions, the OSE remained among the least known components of the ovary until the last few decades, when increasing histopathologic and immunocytochemical evidence from clinical specimens suggested that the OSE might be the source of the most common and lethal of ovarian cancers, i.e. the epithelial ovarian carcinomas (1, 4–6). However, until relatively recently, there were no experimental systems for the study of the origin of these neoplasms. Animal models of epithelial ovarian cancer are not available because, except in aging hens (7), ovarian tumors in other animal species do not arise in OSE but in follicular, stromal or germ cells, and the biology of these tumors is fundamentally different from that of epithelial ovarian cancer. The establishment of culture systems posed problems because of the minute size and limited growth potential in vitro of OSE. In the 1980ties, the first tissue culture systems for OSE from different species (4, 8–13), including human (12, 13), were developed. Subsequently, information about the normal functions of OSE and its relationship to ovarian cancer expanded rapidly. The results of these studies showed that OSE is physiologically much more complex than would be predicted from its inconspicuous appearance, and they support the hypothesis that the ovarian epithelial cancers arise in this simple epithelium. Recently, the capacity of OSE to give rise to ovarian adenocarcinomas was demonstrated experimentally for the first time. This was achieved by introducing SV40 large T antigen and constitutively expressed E-cadherin into normal OSE in culture. The resulting phenotype closely resembled neoplastic OSE, and the cells formed adenocarcinomas in SCID mice (14, 15).

Keywords

Ovarian Cancer Hepatocyte Growth Factor Granulosa Cell Ovarian Surface Epithelium Ovarian Surface 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Nicosia SV, Saunders BO, Acevedo-Duncan ME, Setrakian S, Degregorio R Biopathology of ovarian mesothelium. In: Ultrastructure of the ovary. Familiari G, Makabe S, Motta PM, eds. Kluwer Academic Publishers, 287–310, 1991.CrossRefGoogle Scholar
  2. 2.
    Nicosia SV, Ku Ni Ni K, Oliveros-Saunders B, Giacomini G, Pieno E, Mayer J, Nicosia RF Ovarian mesothelium (surface epithelium) in normal, pathological and experimental conditions In: Recent advances in microscopy of cells, tissues and organs Motta PM ed. pp. 509–517, 1997.Google Scholar
  3. 3.
    Bast RC Jr, Xu F, Yu Y, Fang XJ, Wiener J, Mills GB Overview: the molecular biology of ovarian cancer. In: Ovarian Cancer 5, Sharp F, Backett T, Berek J, Bast R eds. Isis Medical Media Publishers, Oxford, United Kingdom, pp. 87–97, 1998.Google Scholar
  4. 4.
    Nicosia SV, Nicosia RF. Neoplasms of the ovarian mesothelium. In: Pathology of human neoplasms. Azar, HA ed. Raven Press, New York, pp. 435–486, 1998.Google Scholar
  5. 5.
    Herbst AL The epidemiology of ovarian carcinoma and the current status of tumor markers to detect disease. [Review]. Am J Obstet and Gynecol 1994; 170: 1099–105.Google Scholar
  6. 6.
    Auersperg N, Edelson MI, Mok SC, Johnson SW, Hamilton TC. The biology of ovarian cancer. Semin Oncol 1998; 25: 281–304.PubMedGoogle Scholar
  7. 7.
    Fredrickson TN. Ovarian tumors of the hen. Environmental Health Perspectives 1987; 73: 35–51.PubMedCrossRefGoogle Scholar
  8. 8.
    Hamilton TC, Henderson WT, Eaton C. In: Tissue citure in medical Res. (II). Proceedings of 2nd Interni. Symp. Richards RJ and Rajan KT eds. Pergamon press New York, 1980.Google Scholar
  9. 9.
    Adams AT, Auersperg N. Transformation of cultured rat ovarian surface epithelial cells by Kirsten murine sarcoma virus. Cancer Res 1981; 41: 2063–2072.PubMedGoogle Scholar
  10. 10.
    Adams AT, Auersperg N. Autoradiographic investigation of estrogen binding in cultured rat ovarian surface epithelial cells. J Histochem and Cytochem 1983; 31: 1321–1325.CrossRefGoogle Scholar
  11. 11.
    Nicosia SV, Narconis RJ, Saunders BO. Regulation and temporal sequence of surface epithelium morphogenesis in the postovulatory rabbit ovary. In: Developments in Ultrastructure of Reproduction. Alan R Liss, Inc., 1989; 296: 111–119.Google Scholar
  12. 12.
    Auersperg N, Siemens CH, Myrdal SE. Human ovarian surface epithelium in primary culture. In Vitro Cell Dev Biol 1984; 20: 743–755.Google Scholar
  13. 13.
    Siemens CH, Auersperg N. Serial propagation of human ovarian surface epithelium in tissue culture. J Cell Physiol 1998; 134: 347–356.CrossRefGoogle Scholar
  14. 14.
    Auersperg N, Pan J, Grove BD, Peterson T, Fisher J, Maines-Bandiera S, Somasiri A, Roskelley CD. E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci USA 1999; 96: 6249–6254.PubMedCrossRefGoogle Scholar
  15. 15.
    Ong A, Maines-Bandiera SL, Roskelley CD, Auersperg N. An ovarian adenocarcinoma line derived from SV40/E-cadherin transfected normal human ovarian surface epithelium. Int J Cancer 2000; 85: 430–437.PubMedCrossRefGoogle Scholar
  16. 16.
    Byskov AR, Skakkebaek NE, Stafanger G, Peters H. Influence of ovarian surface epithelium and rete ovarii on follicle formation. J Anat 1977; 123: 77–86.PubMedGoogle Scholar
  17. 17.
    Stein LE, Anderson CH. A qualitative and quantitative study of rete ovarii development in the fetal rat: correlation with the onset of meiosis and follicle cell appearance. Anat Rec 1979; 193: 197–212PubMedCrossRefGoogle Scholar
  18. 18.
    Yoshinaga K, Hess DL, Hendrickx AG, Zamboni L The development of the sexually indifferent gonad in the prosimian, Galago crassicaudatus crassicaudatus. Am J Anat 1988; 181: 89–105CrossRefGoogle Scholar
  19. 19.
    Hirshfield AN. Development of follicles in the mammalian ovary. Int Rev Cytol 1991; 124: 43–101.PubMedCrossRefGoogle Scholar
  20. 20.
    Pan J, Auersperg N. Spatiotemporal changes in cytokeratin expression I the neonatal rat ovary. Biochem Cell Biol 1997; 76: 27–35.CrossRefGoogle Scholar
  21. 21.
    Jacobs, Bast Jr RC. The CA 125 tumour-associated antigen: a review of the literature. [Review] Human Reproduction 1989; 4: 1–12.Google Scholar
  22. 22.
    Kabawat SE, Bast RC Jr, Bhan AK, Welch WR, Knapp RC, Colvin RB. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC-125. Int J Gynecol Pathol 1983; 2: 275–85.PubMedCrossRefGoogle Scholar
  23. 23.
    Van Blerkom J, Motta PM. In: The Cellular Basis of Mammalian Reproduction. Urban and Scharzenberg, Baltimore 1979.Google Scholar
  24. 24.
    Blaustein A, Lee H. Surface Cells of the Ovary and Pelvic Peritoneum: A Histochemical and Ultrastructure Comparison. Gynecol Oncol 1979; 8: 34–43.PubMedCrossRefGoogle Scholar
  25. 25.
    Blaustein A, Kaganowicz A, Wells J. Tumor markers in inclusion cysts of the ovary. Cancer 1982; 49: 722–726.PubMedCrossRefGoogle Scholar
  26. 26.
    Nicosia SV, Johnson JH. Surface Morphology of Ovarian Mesothelium (Surface Epithelium) and of Other Pelvic and Extrapelvic Mesothelial Sites in the Rabbit. Int J Gynecol Pathol 1984; 3: 249–260.PubMedCrossRefGoogle Scholar
  27. 27.
    van Niekerk CC, Boerman OC, Ramaekers FCS, Poels LG. Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas. Am J Pathol 1991; 138: 455–463.PubMedGoogle Scholar
  28. 28.
    van Niekerk CC, Jap PHK, Thomas CMG, Smeets DFCM, Ramaekers FCS, Poels LG. Marker profile of mesothelial cells versus ovarian carcinoma cells. Int J Cancer 1989; 43: 1065–1071.PubMedCrossRefGoogle Scholar
  29. 29.
    Auersperg N, Maines-Bandiera SL, Dyck HG, Kruk PA. Characterization of cultured human ovarian surface epithelial cells: phenotypic plasticity and premalignant changes. Lab Invest 1994; 71: 510–518.PubMedGoogle Scholar
  30. 30.
    Zeimet AG, Offner FA, Muller-Holzner E, Widschwendter M, Abendstein B, Fuith LC, Daxenbichler G, Marth C. Peritoneum and Tissues of the Female Reproductive Tract as Physiological Sources of CA-125. Tumor Biol 1998; 19: 275–282.CrossRefGoogle Scholar
  31. 31.
    Kruk PA, Uitto VJ, Firth JD, Dedhar S, Auersperg N. Reciprocal interactions between human ovarian surface epithelial cells and adjacent extracellular matrix. Exp Cell Res 1994; 215: 97–108.PubMedCrossRefGoogle Scholar
  32. 32.
    Cruet S, Salamanca C, Staedel C, Auersperg N avß3/vitronectin expression by normal ovarian surface epithelial cells: role in cell adhesion and cell proliferation. Gynecol Oncol 1999; 75: 254–260.Google Scholar
  33. 33.
    Maines-Bandiera SL, Auersperg N. Increased E-cadherin expression in ovarian surface epithelium: an early step in metaplasia and dysplasia?. Int J Gynecol Pathol 1997; 16: 250255.Google Scholar
  34. 34.
    Peralta Soler A, Knudsen KA, Tecson-Miguel A, McBreaty FX, Han AC, Salazar H. Expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometrioid tumors. Hum Pathol 1997; 28: 734739.Google Scholar
  35. 35.
    Sundfeldt K, Piontkewitz Y, Ivarsson K, Nilsson O, Hellberg P, Brannstrom M, Janson PO, Enerback S, Hedin L. E-Cadherin Expression in Human Epithelial Ovarian Cancer and the Normal Ovary. Int J Cancer 1997; 74: 275–280.PubMedCrossRefGoogle Scholar
  36. 36.
    Wong AST, Maines-Bandiera SL, Rosen B, Wheelock MJ, Johnson KR, Leung PCK, Roskelley CD, Auersperg N. Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: Influence of family history of ovarian cancer. Int J Cancer 1999; 81: 180–188.PubMedCrossRefGoogle Scholar
  37. 37.
    Gillett WR, Mitchell A, Hurst PR. A scanning electron microscopic study of the human ovarian surface epithelium: characterization of two cell types. Hum Reprod 1991; 6: 645650.Google Scholar
  38. 38.
    Mittal KR, Goswami S, Demopoulos RI. Immunohistochemical profile of ovarian inclusion cysts in patients with and without ovarian carcinoma. Histochemical J 1995; 27: 119–122.CrossRefGoogle Scholar
  39. 39.
    Deligdisch L, Einstein A, Guera D, Gil J. Ovarian dysplasia in epithelial inclusion cysts. Cancer 1995; 76: 1027–1034.PubMedCrossRefGoogle Scholar
  40. 40.
    Scully RE Early de novo ovarian cancer and cancer developing in benign ovarian lesions. Int J Gynecol Obstet 1995; 49 Suppl:S9–S15.Google Scholar
  41. 41.
    Scully RE. Pathology of Ovarian Cancer Precursors. J Cell Biochem Suppl 1995; 23: 208–218.PubMedCrossRefGoogle Scholar
  42. 42.
    Radisavljevic S. The pathogenesis of ovarian inclusion cysts and cystomas. Obstet Gynecol 1976; 49: 424–429.Google Scholar
  43. 43.
    Murdoch WJ. Ovarian Surface Epithelium During Ovulatory and Anovulatory Ovine Estrous Cycles. Anat Rec 1994; 240: 322–326.PubMedCrossRefGoogle Scholar
  44. 44.
    Ziltener HJ, Maines-Bandiera S, Schrader JW, Auersperg N. Secretion of bioactive interleukin-1, interleukin-6, and colony-stimulating factors by human ovarian surface epithelium. Biol Reprod 1993; 49: 635–641.PubMedCrossRefGoogle Scholar
  45. 45.
    Berchuck A, Kohler MF, Boente MP, Rodriguez GC, Whitaker RS, Bast Jr RC. Growth regulation and transformation of ovarian epithelium. [Review]. Cancer 1993; 71: 545–551.PubMedCrossRefGoogle Scholar
  46. 46.
    Wu S, Rodabaugh K, Martinez-Maza O, Watson JM, Silberstein DS, Boyer CM, Peters WP, Weinberg JB, Berek JS, Bast RC Jr. Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-alpha. Am J Obstet Gynecol 1992; 166: 997–1007.PubMedGoogle Scholar
  47. 47.
    Wu S, Boyer CM, Whitaker RS, Berchuck A, Wiener JR, Weinberg JB, Bast Jr RC. Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. Cancer Res 1993; 53: 1939–1944.PubMedGoogle Scholar
  48. 48.
    Osterholzer H.. Streibel EJ, Nicosia SV. Growth effects of protein hormones on cultured rabbit ovarian surface epithelial cells. Biol Reprod 1985; 33: 247–258.PubMedCrossRefGoogle Scholar
  49. 49.
    Czernobilsky B. Co-expression of cytokeratin and vimentin filaments in mesothelial, granulosa and rete ovarii cells of the human ovary. Eur J Cell Biol 1985; 37: 175–190.PubMedGoogle Scholar
  50. 50.
    Hornby AE, Pan J, Auersperg N. Intermediate filaments in rat ovarian surface epithelial cells: changes with neoplastic progression in culture. Biochem Cell Biol 1992; 70: 16–25.PubMedCrossRefGoogle Scholar
  51. 51.
    Nakamura M, Katabuchi H, Ohba T, Fukumatsu Y, Okamura H. Isolation, Growth and Characteristics of human ovarian surface epithelium. Virchows Archiv 1994; 424: 59–67.PubMedCrossRefGoogle Scholar
  52. 52.
    Dyck HG, Hamilton TC, Godwin AK Lynch HT, Maines-Bandiera SL, Auersperg N. Autonomy of the epithelial phenotype in human ovarian surface epithelium: changes with neoplastic progression and with a family history of ovarian cancer. Int J Cancer 1996; 69: 429–436.PubMedCrossRefGoogle Scholar
  53. 53.
    Davila RM, Crouch EC. Role of mesothelial and submesothelial stromal cells in matrix remodeling following pleural injury. Am J Pathol 1993; 142: 547–555.PubMedGoogle Scholar
  54. 54.
    Trelstad RL, Hayashi A, Hayashi K, Donahoe PK. The epithelial-mesenchymal interface of the male rat mullerian duct: loss of basement membrane integrity and ductal regression. Devel Biol 1982; 92: 27–40.CrossRefGoogle Scholar
  55. 55.
    Young RH, Clement PB, Scully RE. The Ovarian. In: Diagnostic surgical pathology. Sternberg SS, ed. Raven Press, New York pp. 1655–1734, 1898.Google Scholar
  56. 56.
    van Niekerk CC, Ramaekers FCS, Hanselaar AGJM, Aldeweireldt J, Poels LG. Changes in expression of differentiation markers between normal ovarian cells and derived tumors. Am J of Pathol 1993; 142: 157–177.Google Scholar
  57. 57.
    Godwin AK, Testa J, Handel LM, Liu Z, Vanderveer LA, Tracey PA, Hamilton TC. Spontaneous transformation of rat ovarian surface epithelial cells implicates repeated ovulation in ovarian cancer etiology and is associated with clonal cytogenetic changes. J Natl Cancer Inst 1992; 84: 592–601.PubMedCrossRefGoogle Scholar
  58. 58.
    Testa J, Getts L, Salazar H, Liu Z, Handel LM, Godwin AK, Hamilton TC. Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity. Cancer Res 1994; 54: 2788–2784.Google Scholar
  59. 59.
    Bjersing L, Cajander S. Ovulation and the role of the ovarian surface epithelium. Experientia 1975; 15: 605–608.CrossRefGoogle Scholar
  60. 60.
    Espey LL, Lipner H. Ovulation In: The Physiology of Reproduction. Raven Press, Ltd, New York, Chapter 194; 13: 725–780.Google Scholar
  61. 61.
    Ackerman RC, Murdoch WJ. Prostaglandin-induced apoptosis of ovarian surface epithelial cells. Prostaglandins 1993; 45: 475–485.PubMedCrossRefGoogle Scholar
  62. 62.
    Murdoch WJ. Programmed cell death in preovulatory ovine follicles. Biol Reprod 1995; 53: 8–12.PubMedCrossRefGoogle Scholar
  63. 63.
    Quirk SM, Cowan RG, Huber SH. Fas antigen-mediated apoptosis of ovarian surface epithelial cells. Endocrinol 1997; 138: 4558–4566.CrossRefGoogle Scholar
  64. 64.
    Baldwin RL, Tran H, Karlan BY. Primary ovarian cancer cultures are resistant to Fas-mediated apoptosis. Gynecol Oncol 1999; 74: 265–271.PubMedCrossRefGoogle Scholar
  65. 65.
    Kruk PA, Auersperg N. A line of rat ovarian surface epithelium provides a continuous source of complex extracellular matrix. In Vitro Cell Dev Biol 1994; 30A: 217–225.CrossRefGoogle Scholar
  66. 66.
    Zheng W, Magid MS, Kramer EE, Chen YT. Follicle-stimulating hormone receptor is expressed in human ovarian surface epitheliu and Fallopian tube. Am J Pathol 1996; 148: 47. 53.Google Scholar
  67. 67.
    to Velde ER, Scheffer GJ, Dorland M, Broekmans FJ, Fauser BCJM. Developmental and endocrine aspects of normal ovarian aging. Mol Cell Endocrinol 1998; 145: 67–73.CrossRefGoogle Scholar
  68. 68.
    Elliott WM, Auersperg N. Growth of normal ovarian surface epithelial cells (HOSE) in reduced serum and defined media. J Cell Biol 1990; I II: 58a.Google Scholar
  69. 69.
    Hess S, Gulati R, Peluso JJ. Hepatocyte growth factor induces rat ovarian surface epithelial cell mitosis or apoptosis depending on the presence or absence of an extracellular matrix. Endocrinol 1999; 140: 2908–2916.CrossRefGoogle Scholar
  70. 70.
    Karlan BY, Jones JL, Greenwald M, Lagasse LD. Steroid hormone effects on the proliferation of human ovarian surface epithelium in vitro. Am J Obstet Gynecol 1995; 173: 97–104.PubMedCrossRefGoogle Scholar
  71. 71.
    Lau K-M, Mok SC, Ho S-M. Expression of human estrogen receptor-a and -ß, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells. Proc Natl Acad Sci USA 1999; 96: 5722–5727.PubMedCrossRefGoogle Scholar
  72. 72.
    Kang SK, Choi K-C, Tai C-J, Auersperg N, Leung PCK Estradiol regulates gonadotropinreleasing hormone (GnRH) and its receptor gene expression and modulates the growth inhibitory effects of GnRH in human ovarian surface epithelial and ovarian cancer cells (submitted).Google Scholar
  73. 73.
    Liu Y, Lin L, Zarnegar R. Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary. Mol Cell Endocrinol 1994; 104: 173–181.PubMedCrossRefGoogle Scholar
  74. 74.
    Romagnolo D, Annab LA, Thompson TE, Risinger fl, Terry LA, Barrett JC, Afshari CA. Estrogen Upregulation of BRCA1 expression with no effect on localization. Mol Carcinogenesis 1998; 22: 102–109.CrossRefGoogle Scholar
  75. 75.
    Favy DA, Maurizis J-C, Bignon Y-J, Bernard-Gallon DJ. Prolactin-Dependent Up-Regulation of BRCA1 Expression in Human Breast Cancer Cell Lines. Biochem Biophys Res Commun 1999; 158: 284–291.CrossRefGoogle Scholar
  76. 76.
    Rodriguez GC, Berchuck A, Whitaker RS, Schlossman D, Clarke-Pearson DL, Bast Jr RC. Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. H. Relationship between receptor expression and response to epidermal growth factor. Am J Obs and Gyn 1661; 164: 745–750.Google Scholar
  77. 77.
    Pierro E, Nicosia SV, Saunders B, Fultz CB, Nicosia RF, Mancuso S. Influence of growth factors on proliferation and morphogenesis of rabbit ovarian mesothelial cells in vitro. Biol of Reprod 1996; 54: 660–669.CrossRefGoogle Scholar
  78. 78.
    Mondshein JS, Schomberg DW. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science 1981; 211: 1179–1180.CrossRefGoogle Scholar
  79. 79.
    Hsueh AJW, Welsh TH, Jones PBC. Inhibition of ovarian and testicular steroidogensis by epidermal growth factor. Endocrinol 1981; 108: 2002–2004.CrossRefGoogle Scholar
  80. 80.
    Erickson GF, Case E. Epidermal growth factor antagonizes ovarian theca-interstitial cytodifferentiation. Mol Cell Endocrinol 1983; 31: 71–76.PubMedCrossRefGoogle Scholar
  81. 81.
    Knecht M, Catt KJ. Modulation of cAMP-mediated differentiation in ovarian granulosa cell by epidermal growth factor and platelet-derived growth factor. J Biol Chem 1983; 258: 2789–2794.PubMedGoogle Scholar
  82. 82.
    Oka Y, Orth DN. Human plasma epidermal growth factor/B-urogastrone is associated with blood platelets. J Clin Invest 1983; 72: 249–259.PubMedCrossRefGoogle Scholar
  83. 83.
    Gillet.1Y,Maillet R, Gautier C. Blood supply and lymph supply of the ovary. In: Biology of the ovary, Motta PM and Makabe ESE, eds. Martins Nijhoff Publishers, Boston, pp.86–98,1980.Google Scholar
  84. 84.
    Berchuck A, Rodriguez GC, Kamel A, Dodge RK, Soper JT, Clarke-Pearson DL, Bast Jr RC. Epidermal growth factor receptor expression in normal ovarian epithelium and ovarian cancer. I. Correlation of receptor expression with prognostic factors in patients with ovarian cancer. Am J Obstet Gynecol 1991; 164: 669–674.PubMedGoogle Scholar
  85. 85.
    Jindal SK, Snoey DM, Lobb DK, Dorrington JH. Transforming Growth Factor a Localization and Role in Surface epithelium of Normal Human Ovaries and in Ovarian Carcinoma Cells. Gynecol Oncol 1994; 53: 17–23.PubMedCrossRefGoogle Scholar
  86. 86.
    Owens OJ, Stewart C, Brown I, Leake RE. Epidermal growth factor receptors (EGFR) in human ovarian cancer. Br J Cancer 1991; 64: 907–910.PubMedCrossRefGoogle Scholar
  87. 87.
    Owens OJ, Leake RE Growth factor content in normal and benign ovarian tumours. European J Obstet Gynecol Reprod Biol 1992; 47: 223–228.CrossRefGoogle Scholar
  88. 88.
    Johnson GR, Saeki T, Auersperg N, Gordon AW, Shoyab M, Salomon DS, Stromberg K. Response to and expression of amphiregulin by ovarian carcinoma and normal ovarian surface epithelial cells: nuclear localization of endogenous amphiregulin. Biochemical and Biophysical Research Communications 1991; 180: 481–488.PubMedCrossRefGoogle Scholar
  89. 89.
    Klapper LN, Kirschbaum MH, Sela M, Yarden Y. Biochemical and clinical implications of the ErbB.HER signaling network of growth factor receptors. In: Advances in Cancer Research, Academic Press, pp. 25–79, 2000.Google Scholar
  90. 90.
    Berchuck A, Kamel A, Whitaker R, Kerns B, Olt G, Kinney R, Soper JT, Dodge R, Clarke-Pearson DL, Marks P et al. Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 1990; 50: 4087–4091.PubMedGoogle Scholar
  91. 91.
    Kohler M, Bauknecht T, Grimm M, Birmelin G, Kommoss F, Wagner E. Epidermal growth factor receptor and transforming growth factor alpha expression in human ovarian carcinomas. Eur J Cancer 1992; 28A: 1432–1437.CrossRefGoogle Scholar
  92. 92.
    Aguilar Z, Akita RW, Finn RS, Ramos BL, Pegram MD, Kabbinavar FF, Pietras RJ, Pisacane P, Sliwkowski MX, Slamon DJ. Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells. Oncogene 1999; 18: 6050–6062.PubMedCrossRefGoogle Scholar
  93. 93.
    Dabrow MB, Francesco MR, McBrearty FX, Caradonna S. The effects of platelet-derived growth factor and receptor on normal ad neoplastic human ovarian surface epithelium. Gynecol Oncol 1998; 71: 29–37.PubMedCrossRefGoogle Scholar
  94. 94.
    Marth C, Zeimet AG, Herold M, Brumm C, Windbichler G, Muller-Holzner E, Offner F, Feichtinger H, Zwierzina H, Daxenbichler G. Different effects of interferons, interleukin113 and tumor necrosis factor-a in normal (OSE) and malignant human ovarian epithelial cells. Int J Cancer 1996; 67: 826–830.PubMedCrossRefGoogle Scholar
  95. 95.
    Kang SS, Choi K-C, Cheng KW, Nathwani PS, Auersperg N, Leung PCK 2000 Role of gonadotropin-releasing hormone as an autocrine growth factor in human ovarian surface epithelium. Endocrinol 141: 72–80.CrossRefGoogle Scholar
  96. 96.
    Taipale J, Saharinen J, Keski-Oja J. Extracellular matrix-associated transforming growth factor-ß: Role in cancer cell growth and invasion. In: Advances in Cancer Research, Academic Press, pp. 87–134, 1998.Google Scholar
  97. 97.
    Berchuck A, Rodriguez G, Olt G, Whitaker R, Boente MP, Arrick BA, Clarke-Pearson DL, Bast RC Jr. Regulation of growth of normal ovarian epithelial cells and ovarian cancer cell lines by transforming growth factor-beta. Am J Obstet Gynecol 1992; 166: 676–684.PubMedGoogle Scholar
  98. 98.
    Vigne J-L, Halbumt LL, Skinner MK. Characterization of bovine ovarian surface epithelium and stoma! cells: Identification of Secreted Proteins. Biol Reprod 1994; 51: 1213–1221.PubMedCrossRefGoogle Scholar
  99. 99.
    Evangelou A, Jindal SK, Brown Ti, Letarte M. Down-regulationof transforming growth factor 13 receptors by androgen in ovarian cancer cells. Cancer Res 2000; 60: 929–935.PubMedGoogle Scholar
  100. 100.
    Josso N, Racine C, di Clemente N, Rey R, Xavier F. The role of anti-Mullerian hormone in gonadal develoment. Mol Cell Endocrinol 1998; 145: 3–7.PubMedCrossRefGoogle Scholar
  101. 101.
    Nash DM, Hess SA, White BA, Peluso JJ. Steroidogenic factor-1 regulates the rate of proliferation of normal and neoplastic rat ovarian surface epithelial cells in vitro. Endocrinol 1998; 139: 4663–4671.CrossRefGoogle Scholar
  102. 102.
    Di Blasio AM, Cremonesi L, Vigano P, Ferrari M, Gospodarowicz D, Vignali M, Jaffe RB. Basic fibroblast growth factor and its receptor messenger ribonucleic acids are expressed in human ovarian epithelial neoplasms. Am J Obstet Gynecol 1993; 169: 1517 1523.Google Scholar
  103. 103.
    Di Renzo MF, Olivero M, Katsaros D, Crepald T, Gaglia P, Zola P, Sismondi P, Comoglio PM. Overexpression of the Met/HGF receptor in ovarian cancer. Int J Cancer 1994; 58: 658–662.PubMedCrossRefGoogle Scholar
  104. 104.
    Negami AI, Sasaki H, Kawakami Y, Kamitani N, Kotsuji F, Tominaga T, Nakamura T. Serum human hepatocyte growth factor in human menstrual cycle and pregnancy: a novel serum marker of regeneration and reconstruction of human endometrium. Homone Res 1995; 44 (suppl 2): 42–46.CrossRefGoogle Scholar
  105. 105.
    Parrott JA, Vigne J-L, Chu BZ, Skinner MK. Mesenchymal-epithelial interactions in the ovarian follicle involve keratinocyte and hepatocyte growth factor production by theca] cells and their action on granulosa cells. Endocrinol 1994; 135: 569–575.CrossRefGoogle Scholar
  106. 106.
    Huntsman D, Resau JH, Klineberg E, Auersperg N. Comparison of c-met expression in ovarian epithelial tumors and normal epithelia of the female reproductive tract by quantitative laser scan microscopy. Am J Pathol 1999; 155: 343–348.PubMedCrossRefGoogle Scholar
  107. 107.
    Klominek J, Baskin B, Liu Z, Hauzenberger D. Hepatocyte growth factor/scatter factor stimulates chemotaxis and growth of malignant mesothelioma cells through c-met receptor. Int J Cancer 1998; 76: 240–249.PubMedCrossRefGoogle Scholar
  108. 108.
    Gulati R, Peluso JJ. Opposing actions of hepatocyte growth factor and basic fibroblast growth factor on cell contact, intracellular free calcium levels, and rat ovarian surface epithelial cell viability. Endocrinol 1997; 138: 1847–1856.CrossRefGoogle Scholar
  109. 109.
    Parrott JA, Skinner M. Expression and action of hepatocyte growth factor in human and bovine normal ovarian surface epithelium and ovarian cancer. Biol Reprod 2000; 62: 49 1500.Google Scholar
  110. 110.
    Wong AST, Leung PCK, Auersperg N. Hepatocyte growth factor/scatter factor and its receptor c-MET in cultured human ovarian surface epithelium: influence of family history of ovarian cancer. Proc Soc Study Reprod 1999; 32: 95–96.Google Scholar
  111. 111.
    Kacinski BM, Carter D, Mittal K, Yee LD, Scata KA, Donofrio L, Chambers SK, Wang KI, Yang-Fent T, Rohrschneider LR et al. Ovarian adenocarcinomas express fmscomplementary transcripts and fms antigen, often with coexpression of CSF-1. Am J Pathol 1990; 137: 135–147.PubMedGoogle Scholar
  112. 112.
    Auersperg N, Maines-Bandiera SL, Dyck HG. Ovarian carcinogenesis and the biology of ovarian surface epithelium. [Review] J Cell Physiol 1997; 173, 261–265.PubMedCrossRefGoogle Scholar
  113. 113.
    Nicholaides NC, Papadopoulos N, Liu B et al. Mutations of two PMS homologues in herediatry nonpolyposis colon cancer. Nature 1994; 37: 75–80.CrossRefGoogle Scholar
  114. 114.
    Kote-Jarai Z, Eeles RA. BRCA1, BRCA2 and their possible function in DNA damage response. Br J Cancer 1999; 81: 1099–1102.PubMedCrossRefGoogle Scholar
  115. 115.
    Fan S, Wang JA, Yuan R, Ma Y, Meng Q, Erdos MR, Pestell RG, Fang Yuan, Aubom KJ, Goldberg ID, Rosen EM. BRCAI inhibition of estrogen receptor signaling in transfected cells. Science 1999; 284: 1354–1356.PubMedCrossRefGoogle Scholar
  116. 116.
    Salazar H, Godwin AK, Daly MD, Laub PB, Hogan M, Rosenblum N, Boente MP, Lunch HT, Hamilton T. Microscopic benign and invasive malignant neoplasms and a cancer-prone phenotype in prophylactic oophorectomies. J Nat Cancer Inst 1996; 88: 1810–1820.PubMedCrossRefGoogle Scholar
  117. 117.
    Werness BA, Afify AM, Bielat KL, Eltabbakh GH, Piver MS, Paterson JM. Altered surface and cyst epithelium of ovaries removed prophylactically from women with a family history of ovarian cancer. Hum Pathol 1999; 30: 151–157.PubMedCrossRefGoogle Scholar
  118. 118.
    Sherman ME, Lee JS, Burks RT, Struewing JP, Durman RJ, Hartge P. Histopathologic features of ovaries at increased risk for carcinoma. Int J Gynecol Pathol 1999; 18: 15 1157.Google Scholar
  119. 119.
    Stratton JF, Buckley CH, Lowe D, Ponder BAJ and the United Kingdom Coordinating Committee of Cancer Research (UKCCCR), Familial Ovarian Cancer Study Group. Comparison of prophylactic oophorectomy specimens from carriers and noncarriers of a BRCA I or BRCA2 gene mutation. J Natl Cancer Inst 1999; 91: 626–628.CrossRefGoogle Scholar
  120. 120.
    Kruk PA, Godwin AK, Hamilton TC, Auersperg N. Telomeric instability and reduced proliferative potential in ovarian surface epithelial cells from women with a family history of ovarian cancer. Gynecol Oncol 1999; 73: 229–236.PubMedCrossRefGoogle Scholar
  121. 121.
    Auersperg N, Maines-Bandiera S, Booth JH, Lynch HT, Godwin AK, Hamilton TC. Expression of two mucin antigens in cultured human ovarian surface epithelium: Influence of a family history of ovarian cancer. Am J Obstet Gynecol 1995; 173: 558–565.PubMedCrossRefGoogle Scholar
  122. 122.
    Marrs JA, Nelson J. Cadherin cell adhesion molecules in differentiation and embryogenesis. Int Rev Cytol 1996; 165: 159–205.PubMedCrossRefGoogle Scholar
  123. 123.
    MacCalman CD, Farooki R, Blaschuk OW. Estradiol regulates E-cadherin mRNA levels in the surface epithelium of the mouse ovary. Clin Exp Metastasis 1994; 12: 276–282.PubMedCrossRefGoogle Scholar
  124. 124.
    Sowter HM, Corps AN, Smith SK. Hepatocyte growth factor (HGF) in ovarian epithelial tumour fluids stimulates the migration of ovarian carcinoma cells. Int J Cancer 1999; 83: 476–480.PubMedCrossRefGoogle Scholar
  125. 125.
    Wong AST, Pelech SL, Ehlen T, Leung PCK, Auersperg N Autocrine regulation of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis? (submitted).Google Scholar
  126. 126.
    Goldberg JM, Piver SM, Jishi MF, Blumenson L. Age at onset of ovarian cancer in women with a strong family history of ovarian cancer. Gynecol Oncol 1997; 66: 3–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Alice S. T. Wong
    • 1
  • Nelly Auersperg
    • 1
  1. 1.Department of Obstetrics and GynaecologyUniversity of British ColumbiaVancouverCanada

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