Neocortical Gene Expression Associated with Behavioral Sensitization to Psychostimulants

  • Yasushi Kajii
  • Takanori Hashimoto
  • Asami Umino
  • Toru Nishikawa
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Experience with amphetamine-like psychostimulants, such as amphetamine, methamphetamine (MAP) or cocaine, results in enhanced neuronal and behavioral responses to subsequent drug exposure. This behavioral sensitization, which is believed to be a part of the mechanisms sustaining drug addiction and drug-induced psychosis in human beings1, is a long-lasting adaptation to drugs of abuse based on persistent cellular and neurochemical changes in some specific brain circuits including the ventral tegmental area (VTA), nucleus accumbens (NAc) and cerebral cortex2. This type of brain plasticity seems to require the gene expression that drives the cascade leading to the establishment and maintenance of the sensitized behavioral responsiveness to stimulants or stress because the application of protein synthesis inhibitors blocks the induction of the sensitization3. Therefore, identification of the stimulant-responsive gene expression that is specifically observed under sensitization-inducing conditions affords helpful clues to understanding the molecular and neuronal mechanism of this unique behavioral plasticity.

Keywords

Ventral Tegmental Area Behavioral Sensitization Mesocortical Dopamine Stimulant Sensitization Sensitization Regimen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Yasushi Kajii
    • 1
  • Takanori Hashimoto
    • 1
  • Asami Umino
    • 1
  • Toru Nishikawa
    • 1
    • 2
  1. 1.Department of Mental Disorder Research, National Institute of NeuroscienceNational Center of Neurology and PsychiatryKodaira, TokyoJapan
  2. 2.Section of Psychiatry and Behavioral ScienceTokyo Medical and Dental University Graduate SchoolBunkyo-ku, TokyoJapan

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