G-Protein-Mediated Regulation of P/Q-Type Calcium Channels by α2 and β Adrenergic Receptors Exogenously Expressed in Xenopus Oocytes
In the CNS, opening of voltage-dependent Ca2+ channels (VDCCs) in response to action potentials triggers synaptic neurotransmission. The presynaptic VDCCs consist of three types of Cav2 channel family, formerly known as N-, P/Q- and R-types. Although the modulation of N-type channels by G protein-coupled receptors has been extensively studied so far, little is known about the regulation of P/Q-type channels. To elucidate this point, we have investigated the interaction of α2 and β adrenergic receptors with P/Q-type channels by functional coexpression in Xenopus oocytes.
KeywordsAdrenergic Receptor Xenopus Oocyte Channel Current Cav2 Channel Synaptic Neurotransmission
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