G-Protein-Mediated Regulation of P/Q-Type Calcium Channels by α2 and β Adrenergic Receptors Exogenously Expressed in Xenopus Oocytes

  • Shuji Kaneko
  • Mariko Kinoshita
  • Masaki Kanadzu
  • Akinori Akaike
  • Masamichi Satoh
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

In the CNS, opening of voltage-dependent Ca2+ channels (VDCCs) in response to action potentials triggers synaptic neurotransmission. The presynaptic VDCCs consist of three types of Cav2 channel family, formerly known as N-, P/Q- and R-types. Although the modulation of N-type channels by G protein-coupled receptors has been extensively studied so far, little is known about the regulation of P/Q-type channels. To elucidate this point, we have investigated the interaction of α2 and β adrenergic receptors with P/Q-type channels by functional coexpression in Xenopus oocytes.

Keywords

Adrenergic Receptor Xenopus Oocyte Channel Current Cav2 Channel Synaptic Neurotransmission 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Shuji Kaneko
    • 1
  • Mariko Kinoshita
  • Masaki Kanadzu
  • Akinori Akaike
  • Masamichi Satoh
  1. 1.Department of Neuropharmacology, Graduate School of Pharmaceutical SciencesKyoto UniversitySakyo-ku, KyotoJapan

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