Role of Presynaptic Dopamine D2-Like Receptors in Midbrain Dopaminergic System
Information has been accumulated little by little on the modulatory role of dopamine (DA) in central synaptic transmission. The studies during these several years have reported modulation of central synaptic transmission by D1-like DA receptors located on the presynaptic terminals of GABAergic or glutamatergic fibres.1 More recently, presynaptic D2-like receptor-mediated modulation of central synaptic transmission has been analyzed using electrophysiological techniques. In this chapter, the roles of presynaptic D2-like DA receptors in midbrain DA systems are reviewed, focused mainly on non-NMDA glutamatergic synaptic transmission onto DA-containing neurons in the ventral tegmental area (VTA), and GABAergic transmission onto cholinergic interneurons in the striatum.
KeywordsVentral Tegmental Area Presynaptic Terminal Excitatory Transmission Inhibitory Postsynaptic Current GABAergic Terminal
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