Transcriptional Regulation of the Dopamine β-Hydroxylase Gene

  • Kwang-Soo Kim
  • Hyemyung Seo
  • Chunhyung Kim
  • Dong-Youn Hwang
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Dopamine β-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine and thus is a hallmark protein of noradrenergic (NA) neurons. While DBH is largely co-expressed with tyrosine hydroxylase (TH) in NA and adrenergic neurons, DBH is not expressed in dopaminergic neurons. The highly restricted pattern of DBH expression in the nervous system (typically expressed in >0.0001% of the total neurons) predicts that this gene is subject to neuron-specific as well as to cell type-specific control mechanisms. Therefore, delineation of molecular mechanisms of DBH gene transcription may provide important insight to how NA phenotype is specified during neural development and how its abnormal regulation is related to brain disorders in which NA neurotransmission is dysregulated.

Keywords

Tyrosine Hydroxylase Locus Coeruleus Hydroxylase Gene Adrenergic Neuron Human Dopamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Kwang-Soo Kim
    • 1
  • Hyemyung Seo
    • 1
  • Chunhyung Kim
    • 1
  • Dong-Youn Hwang
    • 1
  1. 1.Molecular Neurobiology Laboratory, McLean HospitalHarvard Medical SchoolBelmontUSA

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