Transcriptional Regulation of the Dopamine β-Hydroxylase Gene
Dopamine β-hydroxylase (DBH) catalyzes conversion of dopamine to norepinephrine and thus is a hallmark protein of noradrenergic (NA) neurons. While DBH is largely co-expressed with tyrosine hydroxylase (TH) in NA and adrenergic neurons, DBH is not expressed in dopaminergic neurons. The highly restricted pattern of DBH expression in the nervous system (typically expressed in >0.0001% of the total neurons) predicts that this gene is subject to neuron-specific as well as to cell type-specific control mechanisms. Therefore, delineation of molecular mechanisms of DBH gene transcription may provide important insight to how NA phenotype is specified during neural development and how its abnormal regulation is related to brain disorders in which NA neurotransmission is dysregulated.
KeywordsTyrosine Hydroxylase Locus Coeruleus Hydroxylase Gene Adrenergic Neuron Human Dopamine
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- Morita S., Kobayashi K., Mizuguchi T., Yamada K., Nagatsu I., Titani K., Fujita K., Hidaka H., Nagatsu T., 1993, The flanking region of the human dopamine ß-hydroxylase gene promotes neuron subtype-specific gene expression in the central nervous system of transgenic mice, Mol. Brain Res. 17:239–244.PubMedCrossRefGoogle Scholar