Cell-Type Specific Gene Regulation of Tyrosine Hydroxylase in the Central Nervous System
Since 1964 when Nagatsu, Levitt and Udenfriend1 identified and partially characterized tyrosine hydroxylase (TH) from the rat adrenal gland as the rate limiting enzyme in the catecholamine (CA) biosynthetic pathway, TH has become one of the most studied enzymes in biochemistry, pharmacology and neuroscience. It has been also widely used as a marker protein for catecholamine neurons in the studies on human brain diseases that include behavioral (Schizophrenia, depression, drug abuse, etc.) and neurodegenerative disorders (Parkinson’s disease).
KeywordsTyrosine Hydroxylase Adrenal Medulla Restraint Stress Tyrosine Hydroxylase Gene Inducible cAMP Early Repressor
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- 4.T. H. Joh, J. H. Son, C. Tinti, B. Conti, S. J. Kim, and S. Cho, Unique and cell-type specific tyrosine hydroxylase gene expression, in: Catecholamines, Bridging basic science with clinical medicine, Adv. Pharmacol, 42, edited by D. S. Goldstein, G. Eisenhoffer, and R. McCarty, (1998) pp. 33–36.Google Scholar