The Noradrenergic Neuron, a Multipeptide Secretory Cell

  • Werner De Potter
  • Zesheng Wang
  • Jan Depreitere
  • Anne-Marie Lambeir
  • Christine Durinx
  • Etienne Nouwen
Chapter
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

It is generally accepted that each neuron can secrete a classical transmitter and one or more peptides via small synaptic vesicles (SS Vs) and large dense-cored vesicles (LDCVs), respectively. According to the current concept both SSVs and LDCVs undergo regulated exocytosis but their release process is differentially regulated. However, this general concept of neurotransmitter release seemed not to hold for sympathetic neurons since the latter store their classical transmitter noradrenaline (NA) not in SSVs but in small dense-cored vesicles (SDCVs) and moreover also in LDCVs together with proteins and peptides. In addition, NA in sympathetic neurons was shown to be released, at least in part, by exocytosis from LDCVs, a finding long disputed but now supported by many recent physiological, pharmacological, electron microscopical and confocal immunomicroscopical studies (De Potter et al., 1997; Annaert et al., 1997). At present the debate merely concerns the part of NA released from SDCV and LDCV.

Keywords

Axonal Transport Sympathetic Neuron Noradrenergic Neuron Chromaffin Granule Exocytotic Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Annaert, W. G., Partoens, P., Slembrouck, D., Bakker, A., Jacob, W., and De Potter, W. P., 1997, Rab3 dissociation and clathrin-mediated endocytosis, two key steps in the exo-endocytotic pathway of large dense cored vesicles.in primary cultures of superior cervical ganglia, Eur. J. Cell Biol. 74:217–229.PubMedGoogle Scholar
  2. De Meester, I., Korom, S., Van Damme, J., and Scharpé, S., 1999, CD26, let it cut or cut it down, Immunol. Today 20:367–375.PubMedCrossRefGoogle Scholar
  3. De Potter, W. P., Partoens, P., and Strecker, S., 1997, Noradrenaline storing vesicles in sympathetic neurons and their putative role in neurotransmitter release: an historical overview of controversial issues, Neurochem.Res. 22:911–919.PubMedCrossRefGoogle Scholar
  4. Dillen, L., Miserez, B., Claeys, M., Aunis, D., and De Potter, W. P., 1993, Post-translational processing of proenkephalins and chromogranins/secretogranins, Neurochem. Int. 22:315–352.PubMedCrossRefGoogle Scholar
  5. Haass, M., Förster, C., Richardt, G., Kranzhöfer, R., and Schömig, A., 1990, Role of calcium channels and protein kinase C for release of norepinephrine and neuropeptide Y, Am. J. Physiol. 259:925–930.Google Scholar
  6. Liang, F., Li, J.-Y., Lovisetti-Scamihorn, P., Coen, E., Depreitere, J., Claeys, M., Wechsung, E., Dahlstrom, A., Winkler, H., and De Potter, W. P., 1999, The processing of secretogranin II in the peripheral nervous system: release of secretoneurin from porcine sympathetic nerve terminals, Brain Res. 818:459–467.PubMedCrossRefGoogle Scholar
  7. Lovisetti-Scamihorn, P., Liang, F., Leitner, B., De Potter, W. P., and Winkler, H., 1999, Pig splenic nerve: peptides derived from chromogranins by proteolytic processing during axonal transport, Regul. Pept. 79: 63–67.PubMedCrossRefGoogle Scholar
  8. Lundberg, J. M., Franco-Cereceda, A., Lou, Y. P., Modin, A., and Pernow, J., 1994, Differential release of classical transmitters and peptides, in: Molecular and Cellular Mechanisms of Transmitter Release, L. Stjarne, P. Greengard, S. Grillner, T. Hokfelt, and D. Ottoson, ed., Raven Press, Ltd, New York, pp. 223–234.CrossRefGoogle Scholar
  9. Mentlein, R., 1999, Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides, Regul. Pept. 85:9–24.PubMedCrossRefGoogle Scholar
  10. Stjarne, L., 2001, Novel dual ‘small’ vesicle model of ATP- and noradrenaline-mediated sympathetic neuromuscular transmission, Auton. Neurosci. 87:16–29.PubMedCrossRefGoogle Scholar
  11. Strecker, S., Partoens, P., Slembrouck, D., Wang, J-M., Courtoy, P.J., Nouwen, E., and De Potter, W.P., 2001, Small dense -cored vesicles are depleted of the classical synaptic vesicle membrane proteins synaptobrevin, synaptotagmin and Rab 3, Neurochem Res 28:173–179.Google Scholar
  12. Wang, Z., Vandenberghe, I., Depreitere, J., Devreese, B., Clerens, S., Nouwen, E. J., Van Beeumen, J., and De Potter, W. P., 2001, Identification and characterization of novel chromogranin B-derived peptides from porcine chromaffin granules by liquid chromatography/electrospray tandem MS, Eur. J. Biochem. 268:235–242.PubMedCrossRefGoogle Scholar
  13. Zukowska-Grojec, Z., Karwatowska-Prokopczuk, E., Rose, W., Rone, J., Movafagh, S., Ji, H., Yeh, Y., Chen, W. T., Kleinman, H. K., Grouzmann, E., and Grant, D. S., 1998, Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium, Circ. Res. 83:187–195.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Werner De Potter
    • 1
  • Zesheng Wang
    • 1
  • Jan Depreitere
    • 1
  • Anne-Marie Lambeir
    • 2
  • Christine Durinx
    • 2
  • Etienne Nouwen
    • 1
  1. 1.Laboratory of NeuropharmacologyUniversity of AntwerpWilrijkBelgium
  2. 2.Laboratory for Medical BiochemistryUniversity of AntwerpWilrijkBelgium

Personalised recommendations