Tetrahydrobiopterin Differentially Regulates the Biosynthesis of Catecholamines and Serotonin

Implication in neuropsychiatric disorders
  • Chiho Sumi-Ichinose
  • Fumi Urano
  • Masayo Kojima
  • Risa Kuroda
  • Hiroaki Shiraishi
  • Takahide Nomura
  • Hiroshi Ichinose
Part of the Advances in Behavioral Biology book series (ABBI, volume 53)

Abstract

Catecholamines, e.g., dopamine (DA), norepinephrine, and epinephrine, and serotonin (5HT) are important neurotransmitters in the brain. They are well known to be involved in the regulation of various aspects of brain function, including emotion, motivation, addiction, aggressiveness, and involuntary movement. Alteration in the metabolism of these monoamines leads to abnormalities in behavior and neuropsychiatric states.

Keywords

Tyrosine Hydroxylase Nerve Terminal Serotonergic Neuron Homozygous Mutant Mouse Sepiapterin Reductase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Chiho Sumi-Ichinose
    • 1
  • Fumi Urano
    • 2
  • Masayo Kojima
    • 2
  • Risa Kuroda
    • 1
  • Hiroaki Shiraishi
    • 1
  • Takahide Nomura
    • 1
  • Hiroshi Ichinose
    • 2
  1. 1.Department of Pharmacology, School of MedicineFujita Health UniversityToyoake, AichiJapan
  2. 2.Institute for Comprehensive Medical ScienceFujita Health UniversityToyoake, AichiJapan

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