Alkaloids pp 239-262 | Cite as

Compartmentation of Alkaloid Synthesis, Transport, and Storage

  • Michael Wink
  • Margaret F. Roberts
Chapter

Abstract

The formation and sequestration of secondary metabolites is often regulated in space and time and correlated with differentiation (Wiermann, 1981). The importance of this correlation has been encountered in undifferentiated plant cell cultures, which either do not produce an alkaloid that is typically present in the intact plant or they accumulate the compounds in very low yields. The comparably few systems that produce high amounts of alkaloids are unfortunately rather the exception (Chapter 7). On the other hand, differentiated organ cultures, such as root or shoot cultures, are very reliable production systems, indicating that it is not the in vivo condition that is responsible for low yields in cell suspension cultures, but rather the degree of differentiation, i.e., differential gene expression of the enzymes involved in alkaloid biosynthesis and alkaloid storage.

Keywords

Alkaloid Biosynthesis Cyanogenic Glycoside Catharanthus Roseus Plant Vacuole Quinolizidine Alkaloid 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Michael Wink
    • 1
  • Margaret F. Roberts
    • 2
  1. 1.Institute for Pharmaceutical BiologyUniversity of HeidelbergHeidelbergGermany
  2. 2.The Centre for Pharmacognosy, School of PharmacyUniversity of LondonLondonEngland

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