CD40 Ligand Knockout Mice

  • Charles R. Maliszewski
  • Mary K. Kennedy
  • Kim A. Campbell
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

CD40 is a 50-kDa glycoprotein expressed on B-cells, monocytes, dendritic cells, follicular dendritic cells, thymic epithelial cells, and certain carcinomas (for review, see ref. 1). Its counterstructure, CD40 ligand (CD40L), is a 33-kDa glycoprotein expressed primarily on activated CD4+ T-cells, but also found on CD8+ T-cells, mast cells, basophils (1), and eosinophils (2). CD40L belongs to the tumor necrosis factor (TNF) superfamily (3), members of which stimulate a broad range of biological functions including proliferation, induction of cytokine secretion, and apoptosis (For review, see ref. 4).

Keywords

Cutaneous Leishmaniasis CD40 Ligand CD40L Expression CD40KO Mouse Cytokine Secretion Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Charles R. Maliszewski
  • Mary K. Kennedy
  • Kim A. Campbell

There are no affiliations available

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