Functional Phenotype of Mice Deficient in the IL-1R Type I Gene

A Comparison with Other Genetically Modified Mice
  • Philip J. Morrissey
  • Moira Glaccum
  • Charles R. Maliszewski
  • Jacques Peschon
Chapter
Part of the Contemporary Immunology book series (CONTIM)

Abstract

Interleukin 1 (IL-1) is a cytokine that is involved in the mechanism of host resistance and immune function (for review, see ref. 1). Evidence indicates that IL-1 functions as a proinflammatory cytokine with significant and well-documented effects on innate resistance and the inflammatory response (2). The biological effects of IL-1 also influence the development of the specific immune response. IL-1 has been long studied as a costimulator of both B-cells and T-cells and the adjuvant effect of IL-1 is well documented (3–5). Thus, it is believed that IL-1 plays a central role in both innate resistance mechanisms and specific immune responses.

Keywords

Mean Fluorescent Intensity Host Resistance Acute Phase Response Specific Immune Response Endotoxic Shock 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Philip J. Morrissey
  • Moira Glaccum
  • Charles R. Maliszewski
  • Jacques Peschon

There are no affiliations available

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