Fatty Acid Regulation of Breast Cancer Cell Growth and Invasion

  • David P. Rose
  • Jeanne M. Connolly
  • Xin-Hua Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 422)

Abstract

In 1993, the American Institute for Cancer Research organized its fourth Annual Symposium around the topic “Diet and Breast Cancer”. At that time, we discussed the influence of dietary fatty acids on human breast cancer cell growth, invasion and metastasis, and described the stimulatory effects of the polyunsaturated omega-6 fatty acids (n-6 FAs), and the inhibitory effects of the long-chain omega-3 fatty acids (n-3 FAs) on both cell proliferation and expression of the metastatic phenotype.1 Since then, progress has been made in understanding the distinct, but complementary, roles of cyclooxygenase and lipoxygenase products of n-6 FA metabolism in breast cancer progression. Also, further support has been obtained for a dietary intervention trial with n-3 FA supplementation, either alone or with selective pharmacological inhibitors of eicosanoid biosynthesis, in women at high breast cancer risk and/or as a novel approach to adjuvant therapy.

Keywords

Breast Cancer Breast Cancer Cell Human Breast Cancer Cell Human Breast Cancer Cell Line Breast Cancer Cell Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • David P. Rose
    • 1
  • Jeanne M. Connolly
    • 1
  • Xin-Hua Liu
    • 1
  1. 1.Division of Nutrition and EndocrinologyAmerican Health FoundationValhallaUSA

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