D1/D2 Dopamine Receptor Interactions in Basal Ganglia Functions

  • John F. Marshall
  • David N. Ruskin
  • Gerald J. LaHoste
Part of the The Receptors book series (REC)

Abstract

The classification by Kebabian and Calne (1) in 1979 of dopamine (DA) receptors into two subtypes (DI and D2) was based on differential linkages to adenylate cyclase as well as on distinct pharmacological profiles. At the time that this classification was proposed, several lines of evidence pointed to a role for D2, but not D1, receptors in the behavioral functions mediated by dopamine.* For instance, in vivo administration of D2 antagonists was known to block the motor stimulant and rewarding properties of agents such as amphetamine or cocaine (3, 4). Administration of D2 agonists produces locomotor activity and stereotyped movements (5). Also, the clinical potencies ofa series of antipsychotic drugs were found to correlate with their affinities for D2 receptors (6, 7). In retrospect, it seems clear that the slowness to recognize the importance of D1 receptor agonism to dopamine’s effects within basal ganglia occurred for two reasons. First, a lack of pharmacological agents specific for DI receptors precluded researchers from isolating the functions of this receptor. Second, as we now appreciate, the influences of D1 receptors can be subtle to detect. The interactions between D1 and D2 receptors are profoundly changed by nigrostriatal injury; and, in intact animals, their interpretation depends on an appreciation of the role played by endogenous DA in providing tonic DI agonism.

Keywords

Firing Rate Dopamine Receptor Dopamine Agonist Striatal Neuron Globus Pallidus Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • John F. Marshall
  • David N. Ruskin
  • Gerald J. LaHoste

There are no affiliations available

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