Chemistry of GABAB Modulators

  • Wolfgang Froestl
  • Stuart J. Mickel
Part of the The Receptors book series (REC)

Abstract

An important step toward understanding the diverse roles of the ubiquitous inhibitory neurotransmitter g-aminobutyric acid (GABA) was Bowery’s discovery that baclofen 1 (Fig. 1) stereospecifically decreases neurotransmitter release in the mammalian central nervous system (CNS) by action at a novel GABA receptor, an effect that was not blocked by bicuculline or other GABA antagonists (Bowery et al., 1980; Hill and Bowery, 1981).

Keywords

Receptor Antagonist Raney Nickel Phosphinic Acid Receptor Partial Agonist Active Gaba 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Wolfgang Froestl
  • Stuart J. Mickel

There are no affiliations available

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