Liver

  • Ralph H. Hruban
  • William H. Westra
  • Timothy H. Phelps
  • Christina Isacson

Abstract

Biopsies of the liver come in two forms: the delicate needle-core biopsy and the larger wedge biopsy. In either case, the specimen should be measured and submitted in its entirety for routine histology. Thin-core biopsies are particularly susceptible to desiccation. Therefore, unless special studies are indicated, biopsies should be placed in fixative in the operating room. The core biopsy can be embedded whole, while the wedge biopsy may be thick enough to warrant sectioning before submitting to the histology laboratory. When sectioning the wedge biopsy, identify the smooth capsule, and then cut the liver at 0.2-cm intervals perpendicular to this surface. Multiple slides should be prepared from each tissue block for histologic evaluation. Step sections are preferred to serial sections so that the intervening sections are available for special stains. If a storage disease is suspected, then a small portion of the biopsy should be placed in glutaraldehyde for electron microscopy.

Keywords

Portal Vein Resection Margin Liver Parenchyma Caudate Lobe Porta Hepatis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Arias IM, Popper H, Shachter D, Shafritz DA. The Liver: Biology and Pathobiology. New York: Raven Press; 1982.Google Scholar
  2. Elias H, Sherrick JC. Morphology of the Liver. New York, NY: Academic Press; 1969.Google Scholar
  3. Sherlock S. Diseases of the Liver and Biliary System. Philadelphia, Pa: FA Davis Co; 1968.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Ralph H. Hruban
    • 1
  • William H. Westra
    • 1
  • Timothy H. Phelps
    • 2
  • Christina Isacson
    • 3
  1. 1.Department of Pathology Meyer 7-181The Johns Hopkins HospitalBaltimoreUSA
  2. 2.Department of Art as Applied to Medicine, School of MedicineThe Johns Hopkins UniversityBaltimoreUSA
  3. 3.Department of PathologyVirginia Mason Medical CenterSeattleUSA

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