Inhibition of Cytochrome P450 Enzymes

  • Paul R. Ortiz de Montellano
  • Maria Almira Correia
Chapter

Abstract

The catalytic cycle of cytochrome P450 (see Chapters 3 and 8) traverses three steps that are particularly vulnerable to inhibition: (1) the binding of substrates, (2) the binding of molecular oxygen subsequent to the first electron transfer, and (3) the catalytic step in which the substrate is actually oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such as agents that interfere with the electron supply to the hemoprotein by accepting electrons directly from cytochrome P450 reductase,1–3 are not discussed here.

Keywords

Aromatase Inhibitor Covalent Binding Microsomal Cytochrome Tienilic Acid Acetylenic Fatty Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Paul R. Ortiz de Montellano
    • 1
  • Maria Almira Correia
    • 2
  1. 1.Department of Pharmaceutical Chemistry, School of PharmacyUniversity of California, San FranciscoSan FranciscoUSA
  2. 2.Department of Cellular and Molecular PharmacologyUniversity of California, San FranciscoSan FranciscoUSA

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