The Prokaryotes pp 3987-3993 | Cite as

The Genus Francisella

  • Francis E. Nano

Abstract

Francisella tularensis was recognized as the causative agent of a febrile illness in three different parts of the world in the early part of the 20th century. McCoy (1911) described a new disease which he found while studying a suspected outbreak of plague in ground squirrels in Tulare County, California. McCoy and Chapin (1912) isolated the etiologic agent of this “plague-like disease” and named the organism Bacterium tularense after the county in which it was found. This organism was also recognized as a disease agent of humans at about the same time. Pearse (1911) described what was known as “deer fly fever” in the area around Brigham City, UT, and Wherry and Lamb (1914) identified B. tularense as the infectious agent of a diseased meat worker in Cincinnati, OH. Edward Francis carried out an extensive series of experiments on the transmission of this organism and on the pathology of the disease he named tularemia (Francis, 1923). Shortly after the description of tularemia in the United States, Ohara (1925) isolated a similar organism (Francis and Moore, 1926) in Japan that caused Yato-byo (hare disease). In 1926, Soviet researchers (Pollitzer, 1967) isolated the same organism from human cases in Siberia. The name of the etiological agent of tularemia has changed over the years from B. tularense, to Pasteurella tularensis, to what it is called today, Francisella tularensis, the latter name in honor of the studies performed with this organism by Francis. In 1950 (Larson et al., 1955), another bacterium was discovered that was eventually placed in the genus Francisella. This organism, F novicida,has only been found twice since its original isolation and apparently has a very low infectivity for humans.

Keywords

Ground Squirrel Hydroxy Fatty Acid Francisella Tularensis Intracellular Growth Live Vaccine Strain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature Cited

  1. Anonymous. 1988. The choice of antimicrobial drugs. Med. Lett. 30: 33–40.Google Scholar
  2. Anderson, R., and A. R. Bhatti. 1986. Fatty acid distribution in the phospholipids of Francisella tularensis. Lipids 21: 669–671.PubMedCrossRefGoogle Scholar
  3. Baker, C. N., D. G. Hollis, and C. Thornsberry. 1985. Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth. J. Clin. Microbiol. 22: 212–215.PubMedPubMedCentralGoogle Scholar
  4. Bell, J. F. 1981. Francisella, p. 172–256. In: H. Blobel and T. Schliber (ed.), Handbuch der bakteriellen infekti-onen bei tieren. Veb Gustav Fisher Verlag. Jena, GermanyGoogle Scholar
  5. Bevanger, L., J. A. Maeland, and A. I. Naess. 1988. Agglutinins and antibodies to Francisella tularensis outer membrane antigens in the early diagnosis of disease during an outbreak of tularemia. J. Clin. Microbiol. 26: 433–437.PubMedPubMedCentralGoogle Scholar
  6. Eigelsbach, H. T., W. Braun, and R. D. Herring. 1951. Studies on the variation on Bacterium tularense. J. Bacteriol. 61: 557–569.PubMedPubMedCentralGoogle Scholar
  7. Eigelsbach, H. T., W. Braun, and R. D. Herring. 1952. Studies on the immunogenic properties of Bacterium tularense variants. J. Infect. Dis. 91: 86–91.PubMedCrossRefGoogle Scholar
  8. Francis, E. 1923. Tularaemia: A new disease of man. Int. Clin. 2: 73–78.Google Scholar
  9. Francis, E., and D. Moore. 1926. Identity of Ohara’s disease and tularemia. J. Am. Med. Assoc. 86: 1329–1332.CrossRefGoogle Scholar
  10. Hollis, D. G., R. E. Weaver, A. G. Steigerwalt, J. D. Wenger, C. W. Moss, and D. J. Brenner. 1989. Francisella philomiragia comb. nov. (formerly Yersinia philomiragia) and Francisella tularensis biogroup novicida (formerly Francisella novicida) associated with human disease. J. Clin. Microbiol. 27: 1601–1608.Google Scholar
  11. Hood, A. M. 1977. Virulence factors of Francisella tularensis. J. Hyg. 79: 47–60.PubMedCrossRefPubMedCentralGoogle Scholar
  12. Jantzen, E., B. P. Berdal, and T. Omland. 1979. Cellular fatty acid composition of Francisella tularensis. J. Clin. Microbiol. 10: 928–930.PubMedPubMedCentralGoogle Scholar
  13. Larson, C. L., W. Wicht, and W. L. Jellison. 1955. A new organism resembling P. tularensis isolated from water. Public Health Rep. 70: 253–258.PubMedCrossRefPubMedCentralGoogle Scholar
  14. Lillie, R. D., and E. Francis. 1937. I. The pathology of tularaemia in man. U.S. Treasury Department, Public Health Service, National Institute of Health Bulletin No. 167Google Scholar
  15. Lofgen, S., A. Tarnvik, M. Thore, and J. Carlsson. 1988. A wild and an attenuated strain of Francisella tularensis differ in susceptibility to hypochlorous acid: A possible explanation of their different handling by polymorphonuclear leukocytes. Infect. Immun. 43: 730–734.Google Scholar
  16. McCoy, G. W. 1911. A plague-like disease of rodents. Public Health Bull. 43: 53–71.Google Scholar
  17. McCoy, G. W., and C. W. Chapin. 1912. Bacterium tularense the cause of a plague-like disease of rodents. Public Health Bull. 53: 17–23.Google Scholar
  18. Merriott, J., A. Shoemaker, and C. M. Downs. 1961. Growth of Pasteurella tularensis in cultured cells. J. Infect. Dis. 108: 136–150.PubMedCrossRefGoogle Scholar
  19. Nano, F E. 1988. Identification of a heat-modifiable protein of Francisella tularensis and molecular cloning of the encoding gene. Microb. Pathogen 5: 109–119.CrossRefGoogle Scholar
  20. Ohara, H. 1925. Concerning an acute febrile disease transmitted by wild rabbits: a preliminary report. Jikken Iho V. 11: 508–523.Google Scholar
  21. Olsufjev, N. G., O. S. Yemelyanova, and T. N. Dunayeva. 1959. Comparative study of strains of B. tularense. II. Evaluation of criteria of virulence of Bacterium tularense in the old and new world. J. Hyg. Epidemiol. Microbiol. Immunol. (Prague) 3: 138–149.Google Scholar
  22. Parker, R. R., E. A. Steinhaus, G. M. Kohls, and W. L. Jel-lison. 1951. Contamination of natural waters and mud with Pasteurella tularensis and Tularemia in beavers and muskrats in the northwestern United States. National Institutes of Health Report No. 193.Google Scholar
  23. Pearse, R. A. 1911. Insect bites. Medical Sentinel 3: 81–82.Google Scholar
  24. Pollitzer, R. 1967. History and incidence of tularemia in the Soviet Union. The Institute of Contemporary Russian Studies, Fordham University, Bronx, NY.Google Scholar
  25. Sandstrom, G., S. Lofgren, and A. Tarnvik. 1988. A capsuledeficient mutant of Francisella tularensis LVS exhibits enhanced sensitivity to killing by serum but diminished sensitivity to killing by polymorphonuclear leukocytes. Infect. Immun. 56: 1194–1202.PubMedPubMedCentralGoogle Scholar
  26. Sandstrom, G., A. Tarnvik, and H. W. Wolf-Watz. 1987. Immunospecific T-lymphocyte stimulation by membrane proteins from Francisella tularensis. J. Clin. Microbiol. 25: 641–644.PubMedPubMedCentralGoogle Scholar
  27. Shepard, C. C. 1959. Nonacid-fast bacteria and HeLa cells: Their uptake and subsequent intracellular growth. J. Bacteriol. 77: 701–714.PubMedPubMedCentralGoogle Scholar
  28. Wherry, W. B., and B. H. Lamb. 1914. Infection of man with Bacterium tularense. J. Infect. Dis. 15: 331–340.CrossRefGoogle Scholar
  29. Young, L. S., D. S. Bicknell, B. G. Archer, J. M. Clinton, L. J. Leavens, J. C. Feeley, and P. S. Brachman. 1969. Tularemia epidemic: Vermont, 1968. N. Engl. J. Med. 280: 1253–1260.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1992

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  • Francis E. Nano

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