Anti-Idiotype Tumor Vaccines

  • Malaya Bhattacharya-Chatterjee
  • Heinz Kohler
Chapter

Abstract

The immunotherapy of human cancer using tumor cells or tumor-derived vaccines has been disappointing for several reasons. It has been consistently difficult to obtain large quantities of pure tumor antigens which are often chemically ill-defined and difficult to purify. In addition, there is the question whether there exists truly tumor-specific antigens and finally, there remains the problem of the immunobiological response potential against tumor antigens, or in other words, the question whether a cancer patient can mount effectively an immune response against his tumor. Tumor-associated antigens are often a part of “self” and usually evoke a very poor immune response in a tumor-bearing host due to a state of T cell-mediated suppression (Haubeck and Kolsch, 1982; Howie and McBride, 1982) and also because of tolerance to the antigen (Greene, 1980; McBride and Howie, 1986). Immunobiologists have learned that a poor antigen can be turned into a strong antigen by simply changing the molecular environment of the haptenic structure. Such changes of the carrier for haptens allow T cell help to become active, making the overall immune response stronger.

Keywords

Tumor Antigen Internal Image Gp37 Antigen Idiotypic Determinant Idiotype Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Malaya Bhattacharya-Chatterjee
    • 1
  • Heinz Kohler
    • 2
  1. 1.Roswell Park Memorial InstituteBuffaloUSA
  2. 2.Dept. of PathologyUniversity of California at San DiegoSan DiegoUSA

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