In Vitro Studies on Docosahexaenoic Acid in Human Platelets

  • M. Lagarde
  • M. Croset
  • M. Hajarine

Abstract

Arachidonic acid (5,8,11,14–20:4 or 20:4w6) is the main polyunsaturated fatty acid of blood and vascular cells and it has been recognized as the precursor of numerous oxygenated derivatives exhibiting a variety of biological activities (1 – 3). In blood platelets, 20:4w6 is almost exclusively located in glycerophospholipids, from where it is fastly mobilized upon cell activation by aggregating agents like thrombin, collagen or the calcium ionophore A 23187 (4–6). Such a mobilization is the limiting step of prostaglandin endoperoxides and thromboxane A2 formation, the potent proaggregatory molecules, as well as of that of 12-lipoxygenase products.

Keywords

Docosahexaenoic Acid Human Platelet Prostaglandin Endoperoxide Lipoxygenase Product Polyenoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M. Lagarde
    • 1
  • M. Croset
    • 1
  • M. Hajarine
    • 1
  1. 1.INSERM U 205, INSA B 406Villeurbanne CedexFrance

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