Nephrotoxicity of Experimental Endotoxaemia in Rats
Endotoxaemia is frequently associated with acute renal failure (ARF) and continues to offer a very poor prognosis despite the recent progress in antibiotic therapy (1). During endotoxaemia an important release of vasoconstrictor and/or dilator hormones have been measured suggesting a that there is a hormonal role in this type of ARF (2). However, the understanding of this pathophysiology is very complex since the renal function is compromised by multifactorial effects such as pre-existing diseases (eg. diabetes, multiple myeloma, etc. ) the frequent administration of potential nephrotoxins (eg. aminoglycoside therapy) and/or prostaglandin inhibitors which all serve to complicate the assessment of renal function. Furthermore, systemic haemodynamic alterations can, per se, affect renal microcirculation.
KeywordsAtrial Natriuretic Peptide Atrial Natriuretic Factor Renal Plasma Flow Filtration Fraction Renal Vascular Resistance
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