Nephrotoxicity pp 601-605 | Cite as

Role of Biotransformation in Acute N-(3,5-Dichlorophenyl)Succinimide-Induced Nephrotoxicity

  • G. O. Rankin
  • D. J. Yang
  • V. J. Teets
  • H. C. Shih
  • P. I. Brown

Abstract

N-(3,5-dichlorophenyl) succimide (NDPS) was developed as an agricultural fungicide during the early 1970s (Fujinami et al, 1972). Although preliminary field testing of NDPS was promising, the usefulness of NDPS as an agricultural fungicide has been limited because of potential toxicity. NDPS has been shown to produce tubular necrosis following acute exposure which is characterized by diuresis, proteinuria, glucosuria, haematuria, increased blood urea nitrogen (BUN) concentration and kidney weight, and decreased organic ion accumulation by renal cortical slices (Rankin, 1982; Rankin et al. , 1985). Chronic exposure to NDPS produces interstitial nephritis (Sugihara et al. , 1975). In addition, NDPS has been shown to promote the activity of several renal carcinogens including the nitrosamines (Ito et al, 197 4) and citrinin (Shinohara et al. , 1976).

Keywords

Interstitial Nephritis Kidney Weight Nephrotoxic Potential Blood Urea Nitrogen Concentration Renal Cortical Slice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • G. O. Rankin
    • 1
  • D. J. Yang
    • 1
  • V. J. Teets
    • 1
  • H. C. Shih
    • 1
  • P. I. Brown
    • 1
  1. 1.Departments of Pharmacology and AnatomyMarshall University School of MedicineHuntingtonUSA

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