Induction of Hyaline Droplet Accumulation in Renal Cortex of Male Rats by Aromatic Compounds
Repeated oral and inhalation exposure of male rats to unleaded gasoline and a variety of petroleum-derived naphthas, solvents, and distillates has been reported to induce a characteristic spectrum of changes in the kidney which has been referred to as “light hydrocarbon nephropathy” (Mehlmann et al., 1984; Craig, 1986). Most of the identified compounds belong to the class of branched-chain alkanes. A select few of the investigated aromatics were inactive (Haider et al., 1984; Halder et al., 1985). Recently, corresponding effects were seen in short- and long-term studies with p-dichlorobenzene (NTP, 1986; Bomhard et al., 1987). Accumulation of hyaline droplets in the tubular epithelium occurs within a few days after treatment with these compounds and precedes the subsequent tubular lesions (Thomas et al., 1985). This study evaluated “light hydrocarbon nephropathy” inducing potential of several aromatic hydrocarbons by histological judgement of hyaline droplet accumulation (HDA).
KeywordsPetroleum Hydrocarbon Inhalation Exposure B6C3F1 Mouse Unleaded Gasoline Bind Site Model
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