Nephrotoxicity pp 423-432 | Cite as

Cannulation of the Bile Duct Protects Against Para-Aminophenol-Induced Nephrotoxicity in the Fischer 344 Rat

  • K. P. R. Gartland
  • C. T. Eason
  • F. W. Bonner
  • J. K. Nicholson

Abstract

Para-aminophenol (PAP) produces necrosis of proximal convoluted tubules acutely in the rat after a single injection (1), and has been demonstrated to be a minor metabolite of paracetamol in the Fischer 344 (F344) rat and Fischer-derived isolated perfused kidney (2). Examination of urine from PAP-treated rats by high resolution proton nuclear magnetic resonance (NMR) spectroscopy revealed dose-related elevations in the urinary excretion of glucose, amino acids, and lactic acid (3, 4) while conventional methods showed enzymuria (4).

Keywords

Proximal Tubule Proton Nuclear Magnetic Resonance Glutathione Conjugate Biliary Cannulation Aminooxyacetic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • K. P. R. Gartland
    • 1
  • C. T. Eason
    • 2
  • F. W. Bonner
    • 2
  • J. K. Nicholson
    • 1
  1. 1.Department of Chemistry, Birkbeck CollegeUniversity of LondonLondonUK
  2. 2.Department of ToxicologySterling-Winthrop Research CentreAlnwick, NorthumberlandUK

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