Nephrotoxicity pp 241-246 | Cite as

Gentamicin-Stimulated Increase in Para-Aminohippurate Uptake in Renal Cortical Slices and Isolated Proximal Tubular Cells

  • E. M. Gordon
  • S. M. McDougall
  • P. H. Whiting
  • G. M. Hawksworth

Abstract

A deleterious effect on renal tubular transport is an important criteria for establishing the nephrotoxic potential of a drug or chemical. In this context the transport of the organic ions p-aminohippurate (PAH) and tetraethylammonium (TEA) into renal cortical slices has been extensively studied (Hirsch, 1976). For example, Kluwe and Hook (1978) have suggested that renal cortical slice transport of organic anions is a sensitive indicator of gentamicin-induced nephrotoxicity.

Keywords

Proximal Tubular Cell Cortical Slice Creatinine Clearance Rate Krebs Ringer Bicarbonate Buffer Proximal Tubular 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • E. M. Gordon
    • 1
  • S. M. McDougall
    • 1
  • P. H. Whiting
    • 1
  • G. M. Hawksworth
    • 1
  1. 1.Clinical Pharmacology Unit and Department of Chemical PathologyUniversity of AberdeenAberdeenUK

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