Nephrotoxicity pp 221-223 | Cite as

Renal Phospholipidosis in Rats after Gentamicin and Pefloxacin Coadministration at Low Doses

  • M.-B. Carlier
  • Z. Kallay
  • P. M. Tulkens

Abstract

Fluoroquinolones constitute a new class of highly active, wide spectrum antimicrobials (see Wolfson & Hooper, 1985; and Hooper & Wolfson, 1985 for review), among which pefloxacin is one of the first to have reached wide clinical usage. Since up to 60% of the administered dose of pefloxacin is eliminated through the kidney, it appears important to examine its potential nephrotoxicity. Moreover, pefloxacin can be administered in combination with an aminoglycoside in order to broaden the spectrum covered by the antiinfective therapy and/or to decrease the risk of emergence of bacterial resistance to either of these drugs (Pechere et al., 1987). Combination of other antibiotics with an aminoglycoside may increase (viz. vancomycin; Wood et al., 1986; Francq-Dufief et al., 1987), or decrease (viz. fosfomycin or piperacillin; Laurent et al., 1985; Carlier et al., 1987) aminoglycoside toxicity. In this connection, we have examined and report here on the influence of pefloxacin on the development of lysosomal phospholipidosis, an early, sensitive and predictive index of aminoglycoside-induced nephrotoxicity in animals and man (see Tulkens, 1986, for review).

Keywords

Proximal Tubular Cell Kidney Cortex Predictive Index Sphingomyelinase Activity Aminoglycoside Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beauchamp, D., G. Laurent, P. Maldague & P.M. Tulkens. 1986. Reduction of gentamicin nephrotoxicity by the concomitant administration of poly-Laspartic acid and and poly-L-asparagine in rats. Arch. Toxicol. Suppl. 9:306–309.PubMedCrossRefGoogle Scholar
  2. Carlier, M.B. 1984. La phospholipidose renale induite par les aminoglycosides: etude biochimique et morphologique. Thesis, Universite Catholique de Louvain. 121 pp.Google Scholar
  3. Carlier, M.B., Z. Kallay, B. Rollmann & P.M. Tulkens. 1987. Reduction of aminoglycoside-induced renal alterations in rats by coadministration of piperacillin at clinically-relevant doses. In: Proceedings of the 15th International Congress of Chemotherapy, Istanbul, Turkey. Ecomed. In press.Google Scholar
  4. Francq-Dufief, M.P., G. Laurent, G. Toubeau, J.A. Heuson-Stiennon & P.M. Tulkens. 1987. Animal evaluation of the nephrotoxic potential associated with aminoglycoside x vancomycin combinations at low doses. In: 27th Intersc. Confer. Antimicrob. Agents Chemother., New York, N.Y. Abstract no. 23.Google Scholar
  5. Hooper, D.C. & J.S. Wolfson. 1985. The fluoroquinolones: pharmacology clinical uses, and toxicities in humans. Antimicrob. Agents Chemother. 28:716–721.PubMedCrossRefGoogle Scholar
  6. Laurent, G., D. Beauchamp, M.B. Carlier, P.M. Tulkens, H. Loibner P. Stutz. 198S. Use of fosfomycin salt of an aminoglycoside (S87351) to decrease its toxicity towards rat kidney cortex. In: 26th Congress of the European Society of Toxicology, Kuopio, Finland. Abstract mo. P22.Google Scholar
  7. Laurent, G., P. Maldague, G. Toubeau, J.AW Heuson-Stiennon & P.M. Tulkens. 1987. Kidney tissue repair after nephrotoxic injury: biochemical and morphological characterization. CRC Crit. Rev. Anat. Sci. In press.Google Scholar
  8. Pechere, J.C., M. Michea-Hamzehpour, R. Auckenthaler, S.P. Regamey. 1987. Ways for limiting emergence of resistance during quinolones therapy of experimental pseudomonas. In: 27th Intersc. Confer. Antimicrob. Agents Chemother., New York, N.Y. Abstract no. 448.Google Scholar
  9. Tulkens, P.M. 1986. Experimental studies on nephrotoxicity of aminoglycosides at low doses: mechanisms and perspectives. Am. J. Med. 80:105–114.PubMedCrossRefGoogle Scholar
  10. Wolfson, J.S. & D.C. Hooper. 1985. The fluoroquinolones: structures, mechanisms of action and resistance, and spectra of activity in vitro. Antimicrob. Agents Chemother. 28:581–586.PubMedCrossRefGoogle Scholar
  11. Wood, C.A., S.J. Kohlhepp, P.W. Kohnen, D.C. Houghton & D.N. Gilbert. 1986. Vancomycin enhancement of experimental tobramycin nephrotoxicity. Antimicrob. Agents Chemother. 30:20–24.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • M.-B. Carlier
    • 1
  • Z. Kallay
    • 1
  • P. M. Tulkens
    • 1
  1. 1.Laboratoire de Chimie Physiologique and International Institute of Cellular and Molecular PathologyUniversite Catholique de LouvainBruxellesBelgium

Personalised recommendations