Nephrotoxicity pp 133-137 | Cite as

Low Molecular Weight Proteins in the Kidney of Copper-Loaded Rats

  • Winston Evering
  • Susan Haywood
  • Jim Trafford

Abstract

A high proportion of renal Cu has been identified (Bremner et al., 1977) bound to the LMWP metallothionein in Cu-loaded rats, and to a lesser extent, in Cu-poisoned sheep. Moreover, Cu-MT administered parenterally to rats was found to be excreted efficiently and preferentially by the kidneys, and during dietary supplementation urinary metallothionein (MT) concentrations increased substantially in Cu-loaded rats (Bremner et al. 1978; 1986) .

Keywords

Particulate Fraction Dietary Copper Copper Toxicosis Rubeanic Acid Major Absorption Peak 
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References

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Winston Evering
    • 1
  • Susan Haywood
    • 1
  • Jim Trafford
    • 1
  1. 1.Department of Veterinary PathologyUniversity of LiverpoolLiverpoolEngland

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