In Vitro and in Vivo HgCl2-Induced Nephrotoxicity Assessed by Tubular Enzymes Release

  • J. C. Cal
  • D. Nerlet
  • J. Cambar

Abstract

The assessment of the nephrotoxicity in clinical practice, as in experimental setting, was based largely on the determination of changes in haemodynamic parameters and electrolytes excretion. However, the acute tubular necrosis involved in many forms of toxic nephropathy is frequently detected and quantified by the evaluation of the urinary activity of marker enzymes form various segments of the nephron. Enzymuria has been shown to be an early and are much a more sensitive index of tubular damage than haemodynamic or electrolyte changes (Price, 1982).

Keywords

Marker Enzyme Mercuric Chloride Acute Tubular Necrosis Electrolyte Excretion Tubular Obstruction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bach, P.H., Ketley, C.P., Benns, S.E., Ahmed, I., and Dixit, M., 1985, The use of isolated and cultured cells in nephrotoxicity — Practice, potential and problems, In: “Renal Heterogeneity and Target Cell Toxicity”, P.H. Bach and E.A. Lock, eds., J. Wiley & Sons, New York, pp. 505.Google Scholar
  2. Batzer, M.A., and Aggarwal, S.K., 1986, An in vitro screening system for the nephrotoxicity of various platinum coordination complexes. A cytochemical study. Cancer Chemother. Pharmacol., 17:209.PubMedCrossRefGoogle Scholar
  3. Guder, W.G., and Ross, B.D., 1984, Enzyme distribution along the nephron, Kidney Int., 26:101.PubMedCrossRefGoogle Scholar
  4. Price, R.G., 1982, Urinary enzymes, nephrotoxicity and renal disease, Toxicology, 23:99.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. C. Cal
    • 1
  • D. Nerlet
    • 1
  • J. Cambar
    • 1
  1. 1.Groupe d’Etude de Physiologie et Physiopathologie Renales Faculté de PharmacieBordeauxFrance

Personalised recommendations