Nephrotoxicity pp 693-698 | Cite as

Species Differences in the Immunocytochemical Distribution of Tamm-Horsfall Glycoprotein

  • C. J. Powell

Abstract

Tamm-Horsfall glycoprotein was first described as a urinary inhibitor of viral haemagglutination (Tamm and Horsfall, 1950). It is a 75,000 dalton molecular weight glycoprotein, which is synthesised in the kidney and excreted in urine. Normal individuals excrete approximately 100 mg per day of this material, which has the ability to form massive aggregates of up to 1.4 × 107 daltons. Tamm-Horsfall glycoprotein contains between 25 and 40% carbohydrate by weight and has a tertiary structure resembling a spiralled string of beads (Wenk et al, 1981). It has a number of unusual chemical and physical properties: such as a ready ability to transform between sol and gel states in solution, according to pH, the ionic environment, its osmotic concentration in solution, and/or the concentration of other solutes (Hoyer and Seiler, 1979).

Keywords

Distal Tubule Distal Nephron Outer Medulla Corticomedullary Junction Distal Nephron Segment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Chambers, R., Groufsky, A., Hunt, J.S., Lynn, K.L. and McGiven, A.R., 1986, Relationship of abnormal Tamm-Horsfall glycoprotein localisation to renal morphology, Clin. Nephrol., 26:21.PubMedGoogle Scholar
  2. Dawnay, A.B. St J., McLean, C. and Cattell, W.R., 1980, The development of a radioimmunoassy for Tamm-Horsfall glycoprotein in serum, Biochem. J., 185:679.PubMedGoogle Scholar
  3. Hoyer, J.R. and Seiler, M.W., 1979, Pathophysiology of Tamm-Horsfall protein, Kid. Int., 16:279.CrossRefGoogle Scholar
  4. Orskov, I., Ferencz, A. and Orskov, A., 1980, Tamm-Horsfall protein or uromucoid is the normal urinary slime that traps type-1 fimbrated Escherichia coli, Lancet, 1:887.PubMedCrossRefGoogle Scholar
  5. Schwartz, R.H., Lewis, R.A. and Schenk, E.A., 1972, Tamm-Horsfall mucoprotein III. Potassium dichromate induced renal tubular damage, Lab. Invest., 27:214.PubMedGoogle Scholar
  6. Shenk, E.A., Schwartz, R.H. and Lewis, R.A., 1971, Tamm-Horsfall mucoprotein I. Localisation in the kidney, Lab. Invest., 25:92.Google Scholar
  7. Sikri, K.L., Foster, C.L., Bloomfield, F.J. and Marshall, R.D., 1979, Localisation by immunofluorescence and by light and electron microscopic immunoperoxidase techniques of Tamm-Horsfall glycoprotein in adult hamster kidney, Biochem. J., 181:523.Google Scholar
  8. Sternberger, L.A., 1974, Immunocytochemistry, 2nd edition, Raven Press, New York.Google Scholar
  9. Tamm, I. and Horsfall, F.L., 1950, Characterisation and separation of an inhibitor of a viral haemagglutination present in urine, Proc. Soc. Exp. Bio. Med., 74:108.Google Scholar
  10. Wenk, R. E. , Bhagavan, B.S. and Rudert, J., 1981, Tamm-Horsfall uromucoprotein and the pathogenesis of casts, reflux nephropathy, and nephritides, In: “Pathology Annual”, H.L. Ioachim, ed., Raven Press, New York, (1981).Google Scholar
  11. Wirdnam, P.K. and Milner, R.D.G., 1984, Tamm-Horsfall glycoprotein release from rat kidney cortex slices in vitro, Clin Sci., 67:529.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • C. J. Powell
    • 1
  1. 1.The Robens InstituteSurrey University GuildfordSurreyUK

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