Recent Advances in Understanding the Immunobiology of Gestational Trophoblastic Disease

A Review
  • Ross S. Berkowitz
  • Donald P. Goldstein
  • Deborah J. Anderson
Part of the Trophoblast Research book series (TR)


Gestational trophoblastic disease, including hydatidiform mole, invasive mole, and choriocarcinoma, comprise a group of interrelated diseases which arise from pregnancy and have varying potentials for local invasion and distant spread. It is now well established that hydatidiform mole may precede the development of persistent gestational trophoblastic tumors including gestational choriocarcinoma (Bagshawe, 1969; Goldstein and Berkowitz, 1982). The results of clinical management of molar pregnancy and gestational trophoblastic tumors has improved considerably over the past three decades due to advances in understanding of the pathology, natural history, and endocrinology of these trophoblastic diseases. In 1956, Li et al. inaugurated a new era in the therapy of gestational choriocarcinoma when they reported curing three women with metastases by treatment with methotrexate. Gestational trophoblastic tumors are now known to be curable with chemotherapy even in the presence of widely metastatic disease. The effective treatment of trophoblastic tumors with chemotherapy represents one of the most dramatic successes in the management of human malignancy.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Ross S. Berkowitz
    • 1
  • Donald P. Goldstein
    • 1
  • Deborah J. Anderson
    • 1
  1. 1.Fearing Research Laboratory New England Trophoblastic Disease Center Division of Gynecologic Oncology Brigham and Women’s Hospital Department of Obstetrics and Gynecology and PathologyHarvard Medical SchoolBostonUSA

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