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Amnionic Association with Chorion and Prostaglandin E2 Production before and after Labor

  • John A. McCoshen
Chapter
Part of the Trophoblast Research book series (TR)

Abstract

Myometrial contractions and cervical ripening associated with the spontaneous initiation of labor appear to be related to alterations in production and metabolism of a variety of prostaglandins by intrauterine tissues (Embrey, 1969; Karim et al., 1969; Karim, 1975; Shepherd, 1976; and Wingerup et al., 1978). Furthermore, while temporal changes in steroidogenesis by both mother and fetus may be involved in the natural termination of pregnancy via prostaglandins (Blocke et al., 1984; KhanDawood and Dawood, 1984; and Mitchell et al., 1982), much attention is now being focused on other possible factors as controlling agents of labor-related prostaglandin synthesis. Specifically, the fetal membranes and decidualized endometrium of pregnancy are suspected important elements in the complex process of labor. Both inhibitory and stimulatory factors of prostaglandin production by amnion have been identified in amniotic fluid, amnionic, chorionic, and decidual tissues (Karim, 1975; Mitchell et al., 1984; Rhenstrom et al., 1983; and Saeed and Mithcell, 1982). Suggestions that the fetal kidney contributes to the amniotic fluid pool of prostaglandins via fetal urine have been proposed (Casey et al., 1983) as well as evidence that fetal urine contains a factor(s) stimulatory to fetal membrane prostaglandin production and the initiation of labor (Strickland et al., 1983). Thus, the hypothesis that the fetus is instrumental in initiating the onset of labor and delivery may have credence in view of the propensity of fetal membranes to produce high concentrations of a variety of prostaglandins. Furthermore, amnionic cells obtained after spontaneous labor onset and vaginal delivery produce more prostaglandins as compared to cells obtained prior to labor (Olson et al., 1983). During the course of labor, amniotic fluid prostaglandins E2 and F2a substantially increase in concentration (Manabe et al., 1983; Nieder and Augustin, 1983).

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References

  1. Block, B.S.B., Liggines, G.C., and Creasy, R.K. (1984) Preterm delivery is not predicted by serial plasma estradiol or progesterone concentration measurements. Am. J. Obstet. Gynecol. 150, 716.PubMedCrossRefGoogle Scholar
  2. Bygdeman, M. (1984) The use of prostaglandins and their analogues for abortion. Clin. Obstet. Gynaecol. 11, 573.PubMedGoogle Scholar
  3. Casey, M.L., Carter, Si, and Mitchell, M.D. (1983) Origin of prostanoids in human amniotic fluid: The fetal kidney as a source of amniotic fluid prostanoids. Am.J. Obstet. Gynecol. 147, 547.PubMedGoogle Scholar
  4. Casey, M.L. and MacDonald, P.C. (1983) Pisseaktis in human amniotic fluid. Presented to the 65th Annual Meeting of the Endocrine Society, San Antonio, Texas. Abstract 600.Google Scholar
  5. Dubin, N.H., Ghodgaonkar, R.B., and King, T.M. (1979) Role of prostaglandin production in spontaneous and oxytocin-induced uterine contractile activity in in vitro pregnant rat uteri. Endocrinol. 105, 47.CrossRefGoogle Scholar
  6. Embrey, M.P. (1969) The effect of prostaglandins on pregnant human uterus. J. Obstet. Gynaecol. Br. Common. 76, 683.Google Scholar
  7. Guzick, D.S. and Winn, K. (1985) The association of chorioamnionitis with preterm delivery. Obstet. Gynecol. 65, 11.PubMedGoogle Scholar
  8. Karim, S.M.M., Trussell, R.R., Hillier, K., and Patel, R.C. (1969) Induction of labor with prostaglandin F20. J. Obstet. Gynaecol. Br. Common. 76, 169.Google Scholar
  9. Karim, S.M.M. (1975) Prostaglandins and Reproduction, pp. 150–178, University Park Press, Baltimore, Maryland.Google Scholar
  10. Khan-Dawood, F.S. and Dawood, M.Y. (1984) Estrogen and progesterone receptor and hormone levels in human myometrium and placenta in term pregnancy. Am. J. Obstet. Gynecol. 150, 501.PubMedCrossRefGoogle Scholar
  11. Lorenz, R.P. Botti, J.J., Chez, R.A., and Bennett, N. (1984) Variations of biologic activity of low-dose prostaglandin E2 on cervical ripening. Obstet. Gynecol. 64, 123.Google Scholar
  12. Manabe, Y., Manabe, A., and Takahashi, A. (1982) F prostaglandin levels in amniotic fluid during balloon-induced cervical softening and labor at term. Prostaglandins 23, 247.PubMedGoogle Scholar
  13. Manabe, Y., Okazaki, T., and Takahashi, A. (1983) Prostaglandin E and F in amniotic fluid during stretch-induced cervical softening and labor at term. Gynecol. Obstet. Invest. 15, 343.Google Scholar
  14. McCoshen, J.A., Chudasama, S., and Tyson, J.E. (1981) Differential responsiveness of cells of human amniotic epithelium to ferritin and 125I-prolactin in vitro. Placenta (Suppl. 3 ), 33.Google Scholar
  15. Mitchell, M.D., Flint,A.P.F., Bibby, J., Brunt, J., Arnold, J.M., Anderson, A., and Turnbull, A. (1977) Rapid increases in plasma prostaglandin concentrations after vaginal examination and amniotomy. Br. Med. J. 2, 1183.Google Scholar
  16. Mitchell, M.D., Bibby, J., Hicks, B.R., and Turnbull, A.C. (1978) Specific production of prostaglandin E2 by tissues from human uterus and fetoplacental unit. Prostaglandins 15, 377.PubMedGoogle Scholar
  17. Mitchell, B., Cruickshank, B., McLean, D., and Challis, J. (1982) Local modulation of progesterone production in human fetal membranes. J. Clin. Endocrinol. Metabol. 55 (6), 1237.CrossRefGoogle Scholar
  18. Mitchell, M., MacDonald, P.C., and Casey, M.L. (1984) Stimulation of prostaglandin E2 synthesis in human amnion cells maintained in monolayer culture by a substance(s) in amniotic fluid. Prosta. Leuko. Med. 15, 399.CrossRefGoogle Scholar
  19. Nieder, J. and Augustin, W. (1983) Increase of prostaglandin E and F equivalents in amniotic fluid during late pregnancy and rapid PGF elevation after cervical dilatation. Prosta. Leuko. Med. 12, 289.Google Scholar
  20. Nimrod, C., Currie, J., Yee, J., Dodd, G., and Persaud, D. (1984) Cervical ripening and labor induction with intracervical triacetin base prostaglandin E gel: A placebo-controlled study. Obstet. Gynecol. 64, 476.Google Scholar
  21. Olson, D.M., Skinner, K., and Challis, J.R.G. (1983) Prostaglandin output in relation to parturition by cells dispersed from human intrauterine tissues. J. Clin. Endocrinol. Metabol. 57 (4), 694.CrossRefGoogle Scholar
  22. Rehnstrom, J., M. Ishikawa, F. Fuchs, and A-R. Fuchs (1983) Stimulation by myometrial and decidual prostaglandin production by amniotic fluid from term, but not mid-trimester pregnancies. Prostaglandins 26 (6), 973.PubMedGoogle Scholar
  23. Saeed, S.A. and Mitchell, M.D. (1982) Stimulants of prostaglandin biosynthesis in human fetal membranes, uterine decidua vera and placenta. Prostaglandins 24 (4), 475.PubMedGoogle Scholar
  24. Schwartz, A.L., Forster, C.S., Smith, P., and Liggins, G.C. (1977) Human amniotic metabolism. I. In vitro maintenance. Am. J. Obstet. Gynecol. 127, 470.Google Scholar
  25. Shepherd, J., Sims, C., and Craft, I. (1976) Extra amniotic E2 and the unfavorable cervix. Lancet ii, 709.Google Scholar
  26. Skinner, K. and Challis, J.R.G. (1985) Changes in the synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor. Am. J. Obstet. Gynecol. 151, 519.Google Scholar
  27. Strickland, D.M., Saeed, S.A., Casey, M.L., and Mitchell, M.D. (1983) Stimulation of prostaglandin biosynthesis by urine of the human fetus may serve as a trigger for parturition. Science 220, 521.PubMedCrossRefGoogle Scholar
  28. Wingerup, L., Andersson, K-E., and Ulmsten, U. (1978) Ripening of the uterine cervix and induction of labor with prostaglandin E2 in viscous gel. Acta Obstet. Gynecol. Scand. 57, 403.Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • John A. McCoshen
    • 1
  1. 1.Department of Obstetrics, Gynecology and Reproductive SciencesUniversity of ManitobaWinnipegCanada

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