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Are There Membrane-Lined Channels through the Trophoblast? A Study with Lanthanum Hydroxide

  • Peter Kaufmann
  • Hobe Schroeder
  • Heinz-Peter Leichtweiss
  • Elke Winterhager
Chapter
Part of the Trophoblast Research book series (TR)

Abstract

Transfer experiments by Stulc et al. (1969) gave evidence for the existence of water-filled routes, so-called pores or channels, across the rabbit placenta. Their radius was calculated to be approximately 10 nm. These findings have been confirmed for the guinea pig placenta by Thornburg and Faber (1977) as well as by Hedley and Bradbury (1980). Morphological studies of both placentae, however, failed to demonstrate structural correlates, i.e., membrane-lined pathways across the trophoblast from the maternal lacunar surface to the basal trophoblastic surface that faces the fetal capillaries (Enders, 1965; Firth and Farr, 1977; Kaufmann and Davidoff, 1977). Among large numbers of syncytiotrophoblastic intracellular membrane systems like endoplasmic reticulum, Golgi cisternae, and absorptive tubules, structures with apparent luminal contacts to either surface are missing. In a recent publication, Gammal (1985) described so-called syncytial channels in the rhesus monkey placenta. These structures reported by Gammal are not comparable with those discussed in the present publication for several reasons: the “channels” described by Gammal are lamellar spaces rather than tubular channels, their luminal diameters range from 50 to 100 nm, and these “channels” are restricted to the superficial zone of the syncytiotrophoblast and never reach the basal trophoblastic surface.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Peter Kaufmann
    • 1
  • Hobe Schroeder
    • 2
  • Heinz-Peter Leichtweiss
    • 2
  • Elke Winterhager
    • 1
  1. 1.Abt. AnatomieRWTH AachenAachenWest Germany
  2. 2.Abt. experimentelle MedizinUniversitaets-FrauenklinikHamburg 20West Germany

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