The Modulation of Glucose Transfer Across the Human Placenta by Intervillous Flow Rates: An In Vitro Perfusion Study

  • Nicholas P. Illsley
  • S. Hall
  • T. E. Stacey
Part of the Trophoblast Research book series (TR)


There is substantial evidence that a high proportion of fetal growth retardation in man is the result of uteroplacental vascular insufficiency. The association of growth retardation with maternal hypertensive disease, cyanotic heart disease and the relationship between growth retardation and low prepregnancy blood volume support the suggestion that chronic flow restriction may result in intrauterine growth retardation (Seeds, 1984). At the same time, in cases of essential hypertension and pre-eclampsia, a reduction in uteroplacental blood flow of 50–60% has been demonstrated (Brown and Veall, 1953; Lunell et al., 1979). Blood flow in growth retarded pregnancies can be reduced by over 50%, even in those women who do not display signs of hypertensive disorders or fetal malformations (Nylund et al., 1983).


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  1. Bissonnette, J.M.(1981) Studies in vivo of glucose transfer across the guinea pig placenta. placenta(Suppl. 2), 155–162.CrossRefGoogle Scholar
  2. Block, B.S., Llanos, A.J., and Creasey, R.K. (1984) Responses of the growth retarded fetus to acute hypoxemia. Am. J. Obstet. Gynecol. 148, 878–885.PubMedCrossRefGoogle Scholar
  3. Brown, J.C.M. and Veall, N. (1953) The maternal placental blood flow in normotensive and hypertensive women. J. Obstet. Gynaecol. Br. Cmwlth. 60, 141–147.CrossRefGoogle Scholar
  4. Bruce, N.W. and Abdul-Karim, R. (1975) Relationships between fetal weight, placental weight and maternal circulation in the rabbit at different stages of gestation. J. Reprod. Fertil. 32, 15–24.Google Scholar
  5. Cartensen, M., Leichtweiss, H-P., Molson, G., and Schröder, H. (1977) Evidence for a specific transport of D-hexoses across the human term placenta in vitro. Arch. Gynakol. 222, 187–196.CrossRefGoogle Scholar
  6. Clapp, J.F., Szeto, H.H., Larrow, R., Hewitt, J., and Mann, L.I. (1980) Umbilical blood flow response to embolization of the uterine circulation. Am. J. Obstet. Gynecol. 138, 60–67.PubMedGoogle Scholar
  7. Garnis, D. (1983) Regional variations in guinea pig uterine blood flow during pregnancy: relationship to intrauterine growth of the fetal-placental unit. Teratol. 27, 101–107.CrossRefGoogle Scholar
  8. Garnis, D. (1984) Intrauterine growth of the guinea pig fetal-placental unit through- out pregnancy: regulation by uteroplacental blood flow. Teratol. 29, 93–99.CrossRefGoogle Scholar
  9. Illsley, N.P., Aarnoudse, J.G., Penfold, P., Bardsley, S.E., Coade, S.B., Stacey, T.E., and Hytten, F.E. (1984) Mechanical and metabolic viability of a placental perfusion system in vitro under oxygenated and anoxic conditions. Placenta 5, 213–225.PubMedCrossRefGoogle Scholar
  10. Illsley, N.P., Hall, S., Penfold, P., and Stacey, T.E. (1985) Diffusional permeability of the human placenta. Contrib. Gynecol. Obstet. 13, 92–97.PubMedGoogle Scholar
  11. Johnson, L.W. and Smith, C.H. (1985) Glucose transport across the basal plasma membrane of human syncytiotrophoblast. Biochim. Biophys. Acta 815, 44–50.PubMedCrossRefGoogle Scholar
  12. Jouppila, P. and Kirkinen, P. (1984) Umbilical vein blood flow as an indicator of fetal hypoxia. Br. J. Obstet. Gynaecol. 91, 107–110.PubMedCrossRefGoogle Scholar
  13. Kollee, L.A.A., Monnens, L.A.H., Trijbels, J.M.F., Veerkamp, J.H., and Jansen, A.J.M. (1979) Experimental intrauterine growth retardation in the rat. Evaluation of the Wigglesworth model. Early Humn. Develop. 3, 295–300.CrossRefGoogle Scholar
  14. Lunell, N-O., Sarby, B., Lewander, R., and Nylund, L. (1979) Comparison of utero-placental blood flow in normal and intrauterine growth retarded pregnancy. Measurements with Indium 113m and a computer linked gamma camera. Gynecol. Obstet. Invest. 10, 106–118.PubMedCrossRefGoogle Scholar
  15. Metcalfe, J., Romney, S.L., Ramsey, L.H., Reid, D.E., and Burwell, C.S. (1955) Estimation of uterine blood flow in normal human pregnancies at term. J. Clin. Invest. 34, 1632–1640.PubMedCentralPubMedCrossRefGoogle Scholar
  16. Myers, S.A., Sparks, J.W., Makowski, E.L., Meschia, G., and Battaglia, F.C. (1982) Relationship between placental blood flow and placental and fetal size in guinea pig. Am. J. Physiol. 243, H404 - H409.PubMedGoogle Scholar
  17. Nylund, L., Lunnell, N-O., Lewander, R., and Sarby, B. (1983) Uteroplacental blood flow index in uterine growth retardation of fetal or maternal origin. Br. J. Obstet. Gynaecol. 90, 16–20.PubMedCrossRefGoogle Scholar
  18. Oh, W., Omori, K., Hobel, C.J., Erenberg, A., and Emmanoulidies, G.C. (1975) Umbilical blood flow and glucose uptake in lamb fetus following single umbilical artery ligation. Biol. Neonate 26, 291–299.PubMedCrossRefGoogle Scholar
  19. Rice, P.A., Rourke, J.E., and Nesbitt, R.E.L. (1976) In vitro perfusion studies of the human placenta. IV. Some characteristics of the glucose transport system in the human placenta. Gynecol. Obstet. Invest. 7, 213–221.CrossRefGoogle Scholar
  20. Saintonge, J. and Rosso, P. (1981) Placental blood flow and transfer of nutrient analogs in large, average and small guinea pig littermates. Ped. Res. 15, 152–156.CrossRefGoogle Scholar
  21. Saintonge, J. and Rosso, P. (1973) Placental blood flow and transfer of nutrient analogues during normal gestation in the guinea pig. Placenta 4, 31–40.CrossRefGoogle Scholar
  22. Schneider, H., Progler, M., and Sodha, R.J. (1985) Effect of flow rate ratio on the diffusion of antipyrine and [3H1 H2O in the isolated dually in vitro perfused lobe of the human placenta. Contrib. Gynecol. Obstet. 13, 114–123.PubMedGoogle Scholar
  23. Seeds, J.W. (1984) Impaired fetal growth: definition and clinical diagnosis. Obstet. Gynecol. 64, 303–310.PubMedGoogle Scholar
  24. Simmons, M.A., Battaglia, F.C., and Meschia, G. (1979) Placental transfer of glucose. J. Dev. Physiol. 1, 227–243.PubMedGoogle Scholar
  25. Stacey, T.E., Boyd, R.D.H., Ward, R.H.T., and Weedon, A.P. (1977) Placental permeability in the sheep. Annal. de Recherches Vet. 8, 345–352.Google Scholar
  26. Widdas, W.F. (1952) Inability of diffusion to account for placental glucose transfer in the sheep and consideration of the kinetics of a possible carrier transfer. J. Physiol. 118, 23–39.PubMedGoogle Scholar
  27. Wier, P.J. and Miller, R.K. (1985) Oxygen transfer as an indicator of perfusion viability in the isolated human placental lobule. Contr. Gynecol. Obstet. 13, 127–131.Google Scholar
  28. Wigglesworth, J.C. (1964) Experimental growth retardation in the fetal rat. J.Pathol. Bacteriol. 88, 1–13.PubMedCrossRefGoogle Scholar
  29. Wootton, R., McFadyen, I.R., and Cooper, J.E. (1977) Measurement of placental blood flow in the pig and its relation to placental and fetal weight. Biol. Neonate 31, 333–339.PubMedCrossRefGoogle Scholar
  30. Yudilevich, D.L., Eaton, B.M., Short, A.H., and Leichtweiss, H-P (1979) Glucose carriers at maternal and fetal sides of the trophoblast in guinea pig placenta. Am. J. Physiol. 236, C205 - C212.Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Nicholas P. Illsley
    • 1
  • S. Hall
    • 1
  • T. E. Stacey
    • 1
  1. 1.Section of Perinatal and Child HealthMRC Clinical Research CentreHarrow, MiddlesexUK

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