Uptake of Ascorbic Acid and Its Oxidized Products in the Isolated Guinea Pig Placenta
Placental transfer of ascorbic acid has been studied in man (Hensleigh and Krantz, 1966; Streeter and Rosso, 1981) and guinea pig (Raiha, 1958; Norkus et al., 1979, 1982). In both, the transfer is assumed to the carrier-mediated. Because the concentrations of total ascorbic acid in plasma and tissue are higher in the fetus than in the mother (Wahren and Rundqvist, 1937; Moller-Christensen and Thorup, 1940; Lund and Kimble, 1943; Raiha, 1958) two different modes of transport are assumed: 1) The transport of ascorbic acid is energy dependent and moves uphill (Hensleigh and Krantz, 1966) and 2) Only the oxidized form of ascorbic acid, that is dehydroascorbic acid, is transferred into the fetus by passive carrier mediated diffusion, where it is reduced to ascorbic acid (Raiha, 1958; Norkus et al., 1979). These hypotheses have not been sufficiently verified until now. It is not known whether ascorbic acid, its oxidized products, or both are transported in the placenta.
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