Nucleotide Interconversion and Breakdown in the Dually Perfused Guinea Pig Placenta

  • Bernard van Kreel
  • J. P. van Dijk
  • A. M. C. M. Pijnenburg
Part of the Trophoblast Research book series (TR)


Alterations in placental purine metabolism can occur due to diminished oxygen supply during labor (van Kreel and Wallenburg, 1980; Wallenburg and van Kreel, 1980; van Kreel and van Dijk, 1982). To study purine metabolism in the placenta without interference from other organs perfusion of the isolated placenta, or organ culture of trophoblastic cells can be used (Vettenranta and Raivo, 1984). The first objective of this study was to investigate nucleotide breakdown in placental tissue, and to quantitate the extraction of nucleosides and purines during perfusion under various experimental conditions of oxygen supplementation.


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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Bernard van Kreel
    • 1
  • J. P. van Dijk
    • 1
  • A. M. C. M. Pijnenburg
    • 1
  1. 1.Department of Chemical PathologyErasmus University RotterdamRotterdamThe Netherlands

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